Characterization of porous media
View Patent ↗Porous filter media and methods for characterizing, selecting and using such media based on their dynamic wettability are disclosed. The dynamic wettability of a medium is a measure of how quickly a given liquid is absorbed by the medium.
1. A method for separating blood components with a biological filter membrane comprising:
providing a device having a fluid inlet, fluid outlet, a flow path therebetween and a porous biocompatible membrane suitable for contact with blood components between said inlet and outlet wherein said membrane has been selected based on its dynamic wettability as determined by an observed rate of absorption of a liquid at a plurality of selected time intervals;
introducing a biological liquid including at least two blood components into said flow path through said inlet;
contacting said porous membrane with said biological liquid.
2. The method of claim 1 wherein said membrane has a dynamic wettability comparable to the dynamic wettability of a second porous membrane having a desired biological interaction with said biological liquid.
3. The method of claim 2 wherein said membrane has been selected on the basis of having a dynamic wettability that is slower than a dynamic wettability of a substantially identical second membrane.
4. The method of claim 1 wherein said liquid comprises blood plasma.
5. The method of claim 1 wherein including introducing said biological liquid into said flow path and passing at least some of said blood components through said selected membrane.
6. The method of claim 5 comprising passing at least blood plasma and platelets through said membrane.
7. The method of claim 1 comprising providing a membrane made of a polymeric material on a polymeric support.
8. The method of claim 7 wherein said polymeric material comprises nylon and said polymeric support comprises a woven polyester mesh.
9. The method of claim 2 wherein said desired biological interaction is a reduced level of platelet adhesion to the membrane surface.
10. A device for separating components of a biological liquid comprising:
a housing including an inlet port and an outlet port and flow path therebetween;
a porous biocompatible membrane suitable for contact with a biological liquid located in proximity to said flow path, wherein said membrane is selected on the basis of its dynamic wettability as determined by an observed rate of absorption of a liquid at a plurality of selected time intervals.
11. The device of claim 10 wherein said membrane has a dynamic wettability that is slower than a pre-determined faster dynamic wettability of a substantially identical second membrane.
12. The device of claim 10 comprising wherein said membrane is disposed within said flow path.
13. The device of claim 10 wherein said device further comprising a rotor within said housing including said membrane on the outer surface thereof.
14. The device of claim 10 including a porous membrane for separating white blood cells from blood.