N-sulfonylurea apoptosis promoters
Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
1. A compound of formula (I)
or a therapeutically acceptable salt thereof, wherein
A is dihydropyridine or tetrahydropyridine;
R 1 is nitro;
R 2 and R 3 are independently selected from the group consisting of hydrogen and —NR 5 R 6 ;
R 4 is phenyl; and
R 5 and R 6 are independently selected from the group consisting of hydrogen, and phenylsulfanylalkyl R 15 is hydrogen.
2. The compound selected from the group consisting of N-{[4-({(1R)-5-(dimethylamino)-1-[(phenylthio)methyl]pentyl}amino)-3-nitrophenyl]sulfonyl}-4-(4-fluorophenyl)-3,6-dihydropyridine -1(2H)-carboxamide and 4-{4-[acetyl(benzyl)amino]phenyl}-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}-3,6-dihydropyridine-1(2H)-carboxarnide.