Methods for treating joint pain using poly-gamma-glutamic acid
View Patent ↗Methods for treating joint pain such as temporomandibular joint disorders, osteoarthritis of the knee, hip and other types of inflammatory joint diseases. The methods involve the use of poly-gamma-glutamic acid.
1. A method of treating a degenerative joint disease, comprising:
providing pharmaceutical grade poly-gamma-glutamic acid (PGGA);
aseptically formulating the PGGA at a concentration of at least about 10 mg/ml;
loading the aseptically formulated PGGA into a syringe; and
placing the formulated PGGA into a diseased joint by interarticular injection.
2. The method of claim 1 , wherein the PGGA has a molecular weight of at least about 250,000 Daltons.
3. The method of claim 2 wherein the PGGA has a molecular weight of at least about 1 million Daltons.
4. A method of treating a degenerative joint disease, comprising:
providing pharmaceutical grade poly-gamma-glutamic acid (PGGA) having a molecular weight of at least about 250,000 Daltons;
aseptically formulating the PGGA at a concentration of from about 10 mg/ml to about 30 mg/ml;
loading the aseptically formulated PGGA into a syringe; and
placing the PGGA into a diseased joint by interarticular injection.
5. The method of claim 4 wherein the PGGA has a molecular weight of at least about 1 million Daltons.