Aminoindazole derivatives active as kinase inhibitors
Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
1. A compound, optionally in the form of a pharmaceutically acceptable salt, said compound including an A group having any one of meanings A00 to A71 which are as follows:
Fragment
Code
A00
A01
A02
A03
A04
A05
A06
A07
A08
A09
A10
A11
A12
A13
A14
A15
A16
A17
A18
A20
A21
A22
A23
A24
A25
A26
A27
A29
A30
A31
A32
A33
A35
A36
A37
A38
A39
A40
A41
A43
A44
A45
A46
A47
A48
A50
A51
A52
A53
A54
A55
A56
A57
A58
A59
A60
A61
A62
A64
A65
A66
A67
A68
A69
A70
A71
a B group having any one of meanings B01 to B74
Fragment
Code
B01
B02
B03
B04
B05
B06
B07
B08
B09
B10
B11
B12
B13
B14
B15
B16
B17
B18
B19
B20
B21
B22
B23
B24
B25
B26
B27
B28
B29
B31
B32
B33
B35
B36
B40
B41
B42
B43
B44
B45
B46
B47
B48
B49
B50
B51
B52
B53
B54
B55
B56
B57
B58
B59
B61
B62
B63
B64
B65
B66
B67
B68
B69
B70
B71
B72
B73
B74
B75
B76
B77
B78
B79
B80
B81
B82
B83
and the remainder of the compound having the structure M1 or M2, wherein the compound has the structure:
said compound selected from the group consisting of:
A00-M1-B36
A00-M1-B31
A00-M1-B33
A00-M2-B68
A00-M2-B15
A00-M2-B35
A00-M2-B33
A00-M1-B68
A00-M1-B63
A00-M1-B78
A00-M1-B79
A00-M1-B62
A00-M1-B64
A00-M1-B66
A00-M1-B17
A00-M1-B74
A00-M1-B76
A00-M1-B65
A00-M2-B83
A00-M1-B72
A29-M1-B36
A31-M1-B36
A35-M1-B36
A40-M1-B36
A38-M1-B31
A03-M1-B31
A31-M1-B31
A35-M1-B31
A29-M1-B15
A31-M1-B15
A35-M1-B15
A32-M1-B15
A38-M1-B35
A29-M1-B35
A31-M1-B35
A35-M1-B35
A39-M1-B35
A40-M1-B35
A29-M1-B33
A38-M2-B36
A45-M2-B36
A03-M2-B36
A29-M2-B36
A31-M2-B36
A44-M2-B36
A46-M2-B36
A35-M2-B36
A32-M2-B36
A41-M2-B36
A39-M2-B36
A40-M2-B36
A45-M2-B31
A03-M2-B31
A31-M2-B31
A44-M2-B31
A46-M2-B31
A35-M2-B31
A41-M2-B31
A39-M2-B31
A40-M2-B31
A29-M2-B15
A31-M2-B15
A35-M2-B15
A32-M2-B15
A29-M2-B35
A31-M2-B35
A44-M2-B35
A35-M2-B35
A32-M2-B35
A41-M2-B35
A38-M2-B33
A03-M2-B33
A29-M2-B33
A44-M2-B33
A46-M2-B33
A35-M2-B33
A41-M2-B33
A39-M2-B33
A40-M2-B33
A30-M1-B29
A31-M1-B29
A29-M1-B29
A03-M1-B29
A37-M1-B29
A30-M2-B29
A31-M2-B29
A29-M2-B29
A03-M2-B29
A41-M2-B01
A32-M2-B32
A47-M2-B32
A48-M2-B32
A43-M2-B32
A33-M1-B32
A35-M1-B32
A31-M1-B01
A36-M1-B01
A29-M1-B01
A01-M1-B01
A01-M2-B01
A03-M1-B01
A03-M2-B01
A04-M1-B01
A04-M2-B01
A05-M1-B01
A05-M2-B01
A06-M1-B01
A07-M1-B01
A07-M2-B01
A08-M1-B01
A09-M1-B01
A09-M2-B01
A10-M1-B01
A10-M2-B01
A11-M1-B01
A11-M2-B01
A12-M1-B01
A13-M2-B01
A13-M1-B01
A14-M1-B01
A15-M1-B01
A16-M1-B01
A17-M1-B01
A18-M2-B01
A18-M1-B01
A20-M1-B01
A21-M1-B01
A22-M1-B01
A23-M1-B01
A24-M1-B01
A25-M1-B01
A26-M1-B01
A27-M2-B01
A01-M1-B02
A01-M2-B02
A02-M1-B02
A02-M2-B02
A03-M1-B02
A04-M1-B02
A04-M2-B02
A05-M1-B02
A05-M2-B02
A06-M1-B02
A07-M1-B02
A07-M2-B02
A08-M1-B02
A08-M2-B02
A09-M1-B02
A09-M2-B02
A10-M1-B02
A11-M1-B02
A11-M2-B02
A12-M1-B02
A13-M2-B02
A13-M1-B02
A14-M1-B02
A15-M1-B02
A16-M1-B02
A17-M1-B02
A18-M2-B02
A18-M1-B02
A20-M1-B02
A21-M1-B02
A22-M1-B02
A23-M1-B02
A24-M1-B02
A25-M1-B02
A26-M1-B02
A27-M2-B02
A01-M1-B03
A01-M2-B03
A02-M1-B03
A02-M2-B03
A03-M1-B03
A04-M1-B03
A04-M2-B03
A05-M1-B03
A06-M1-B03
A06-M2-B03
A07-M1-B03
A07-M2-B03
A08-M1-B03
A08-M2-B03
A09-M1-B03
A09-M2-B03
A10-M1-B03
A11-M1-B03
A11-M2-B03
A12-M1-B03
A12-M2-B03
A14-M1-B03
A15-M1-B03
A16-M1-B03
A17-M1-B03
A18-M2-B03
A18-M1-B03
A20-M1-B03
A21-M1-B03
A22-M1-B03
A23-M1-B03
A24-M1-B03
A25-M1-B03
A26-M1-B03
A27-M2-B03
A01-M1-B04
A01-M2-B04
A02-M1-B04
A02-M2-B04
A03-M1-B04
A03-M2-B04
A04-M1-B04
A04-M2-B04
A05-M1-B04
A05-M2-B04
A06-M1-B04
A06-M2-B04
A07-M1-B04
A07-M2-B04
A08-M1-B04
A08-M2-B04
A09-M1-B04
A09-M2-B04
A10-M1-B04
A11-M1-B04
A11-M2-B04
A12-M1-B04
A13-M2-B04
A13-M1-B04
A14-M1-B04
A15-M1-B04
A16-M1-B04
A17-M1-B04
A18-M2-B04
A18-M1-B04
A20-M1-B04
A21-M1-B04
A22-M1-B04
A23-M1-B04
A24-M1-B04
A25-M1-B04
A26-M1-B04
A27-M2-B04
A01-M1-B05
A01-M2-B05
A02-M1-B05
A02-M2-B05
A03-M1-B05
A04-M1-B05
A04-M2-B05
A05-M1-B05
A05-M2-B05
A06-M1-B05
A06-M2-B05
A07-M1-B05
A07-M2-B05
A08-M1-B05
A08-M2-B05
A09-M1-B05
A09-M2-B05
A10-M2-B05
A11-M1-B05
A11-M2-B05
A12-M1-B05
A13-M2-B05
A13-M1-B05
A14-M1-B05
A15-M1-B05
A16-M1-B05
A17-M1-B05
A18-M2-B05
A21-M1-B05
A26-M1-B05
A27-M2-B05
A01-M1-B06
A01-M2-B06
A02-M1-B06
A02-M2-B06
A03-M1-B06
A03-M2-B06
A04-M1-B06
A04-M2-B06
A05-M1-B06
A05-M2-B06
A06-M2-B06
A06-M1-B06
A07-M2-B06
A07-M1-B06
A08-M2-B06
A08-M1-B06
A09-M2-B06
A09-M1-B06
A10-M2-B06
A10-M1-B06
A11-M1-B06
A12-M2-B06
A12-M2-B06
A13-M1-B06
A14-M1-B06
A16-M1-B06
A17-M1-B06
A18-M2-B06
A18-M1-B06
A20-M1-B06
A21-M1-B06
A22-M1-B06
A23-M1-B06
A24-M1-B06
A25-M1-B06
A26-M1-B06
A27-M2-B06
A01-M1-B07
A01-M2-B07
A02-M1-B07
A02-M2-B07
A03-M1-B07
A04-M1-B07
A04-M2-B07
A05-M1-B07
A06-M1-B07
A06-M2-B07
A07-M1-B07
A07-M2-B07
A08-M1-B07
A08-M2-B07
A09-M1-B07
A09-M2-B07
A10-M1-B07
A11-M1-B07
A11-M2-B07
A12-M1-B07
A13-M2-B07
A14-M1-B07
A15-M1-B07
A16-M1-B07
A17-M1-B07
A18-M2-B07
A18-M1-B07
A20-M1-B07
A21-M1-B07
A22-M1-B07
A23-M1-B07
A24-M1-B07
A25-M1-B07
A26-M1-B07
A27-M2-B07
A01-M1-B08
A01-M2-B08
A02-M1-B08
A03-M1-B08
A04-M1-B08
A05-M1-B08
A05-M2-B08
A06-M1-B08
A06-M2-B08
A07-M1-B08
A07-M2-B08
A08-M1-B08
A08-M2-B08
A09-M1-B08
A09-M2-B08
A10-M1-B08
A10-M2-B08
A11-M1-B08
A11-M2-B08
A12-M1-B08
A12-M2-B08
A13-M1-B08
A14-M1-B08
A15-M1-B08
A16-M1-B08
A17-M1-B08
A18-M2-B08
A18-M1-B08
A20-M1-B08
A21-M1-B08
A22-M1-B08
A23-M1-B08
A24-M1-B08
A25-M1-B08
A26-M1-B08
A27-M2-B08
A01-M1-B09
A01-M2-B09
A02-M1-B09
A02-M2-B09
A03-M1-B09
A03-M2-B09
A04-M1-B09
A04-M2-B09
A05-M1-B09
A05-M2-B09
A06-M1-B09
A06-M2-B09
A07-M1-B09
A07-M2-B09
A08-M1-B09
A08-M2-B09
A09-M1-B09
A09-M2-B09
A10-M1-B09
A10-M2-B09
A11-M1-B09
A11-M2-B09
A12-M1-B09
A12-M2-B09
A13-M2-B09
A13-M1-B09
A14-M1-B09
A15-M1-B09
A16-M1-B09
A17-M1-B09
A18-M2-B09
A18-M1-B09
A20-M1-B09
A21-M1-B09
A22-M1-B09
A23-M1-B09
A24-M1-B09
A25-M1-B09
A26-M1-B09
A27-M2-B09
A01-M1-B10
A01-M2-B10
A02-M1-B10
A03-M1-B10
A03-M2-B10
A04-M1-B10
A04-M2-B10
A05-M1-B10
A05-M2-B10
A06-M1-B10
A07-M1-B10
A07-M2-B10
A08-M1-B10
A08-M2-B10
A09-M1-B10
A10-M1-B10
A10-M2-B10
A11-M1-B10
A11-M2-B10
A12-M1-B10
A12-M2-B10
A14-M1-B10
A15-M1-B10
A16-M1-B10
A18-M2-B10
A18-M1-B10
A20-M1-B10
A21-M1-B10
A22-M1-B10
A23-M1-B10
A24-M1-B10
A25-M1-B10
A26-M1-B10
A27-M2-B10
A02-M1-B11
A02-M2-B11
A03-M1-B11
A03-M2-B11
A04-M1-B11
A04-M2-B11
A05-M1-B11
A05-M2-B11
A06-M1-B11
A07-M2-B11
A08-M1-B11
A08-M2-B11
A10-M1-B11
A10-M2-B11
A11-M2-B11
A12-M2-B11
A13-M2-B11
A14-M1-B11
A15-M1-B11
A16-M1-B11
A17-M1-B11
A18-M2-B11
A18-M1-B11
A20-M1-B11
A21-M1-B11
A22-M1-B11
A23-M1-B11
A24-M1-B11
A25-M1-B11
A26-M1-B11
A27-M2-B11
A01-M1-B12
A02-M1-B12
A02-M2-B12
A03-M1-B12
A03-M2-B12
A04-M1-B12
A05-M1-B12
A05-M2-B12
A06-M1-B12
A07-M1-B12
A07-M2-B12
A08-M1-B12
A09-M1-B12
A09-M2-B12
A10-M1-B12
A10-M2-B12
A11-M1-B12
A11-M2-B12
A12-M1-B12
A13-M1-B12
A14-M1-B12
A15-M1-B12
A16-M1-B12
A17-M1-B12
A18-M2-B12
A18-M1-B12
A20-M1-B12
A21-M1-B12
A22-M1-B12
A23-M1-B12
A24-M1-B12
A25-M1-B12
A26-M1-B12
A27-M2-B12
A01-M1-B13
A02-M1-B13
A03-M1-B13
A12-M1-B13
A13-M1-B13
A14-M1-B13
A18-M2-B13
A20-M1-B13
A22-M1-B13
A27-M2-B13
A01-M1-B14
A01-M2-B14
A02-M1-B14
A03-M1-B14
A03-M2-B14
A04-M1-B14
A04-M2-B14
A05-M1-B14
A05-M2-B14
A06-M1-B14
A07-M1-B14
A07-M2-B14
A08-M1-B14
A08-M2-B14
A09-M1-B14
A09-M2-B14
A10-M1-B14
A10-M2-B14
A11-M1-B14
A11-M2-B14
A12-M2-B14
A13-M1-B14
A14-M1-B14
A15-M1-B14
A16-M1-B14
A17-M1-B14
A18-M2-B14
A18-M1-B14
A20-M1-B14
A21-M1-B14
A22-M1-B14
A23-M1-B14
A24-M1-B14
A25-M1-B14
A26-M1-B14
A27-M2-B14
A01-M1-B15
A01-M2-B15
A02-M1-B15
A02-M2-B15
A03-M1-B15
A04-M1-B15
A04-M2-B15
A05-M1-B15
A05-M2-B15
A06-M1-B15
A07-M1-B15
A08-M1-B15
A08-M2-B15
A09-M1-B15
A09-M2-B15
A10-M1-B15
A11-M1-B15
A11-M2-B15
A12-M1-B15
A12-M2-B15
A13-M2-B15
A13-M1-B15
A20-M1-B15
A02-M1-B16
A05-M1-B16
A06-M1-B16
A08-M1-B16
A11-M1-B16
A14-M1-B16
A15-M1-B16
A16-M1-B16
A17-M1-B16
A18-M1-B16
A04-M1-B16
A20-M1-B16
A21-M1-B16
A22-M1-B16
A23-M1-B16
A24-M1-B16
A25-M1-B16
A26-M1-B16
A15-M1-B17
A16-M1-B17
A17-M1-B17
A18-M1-B17
A20-M1-B17
A21-M1-B17
A22-M1-B17
A23-M1-B17
A24-M1-B17
A25-M1-B17
A26-M1-B17
A02-M1-B18
A05-M1-B18
A06-M1-B18
A08-M1-B18
A10-M1-B18
A11-M1-B18
A12-M1-B18
A14-M1-B18
A15-M1-B18
A16-M1-B18
A17-M1-B18
A18-M1-B18
A04-M1-B18
A20-M1-B18
A21-M1-B18
A22-M1-B18
A23-M1-B18
A24-M1-B18
A25-M1-B18
A26-M1-B18
A02-M1-B19
A05-M1-B19
A06-M1-B19
A08-M1-B19
A10-M1-B19
A11-M1-B19
A12-M1-B19
A14-M1-B19
A15-M1-B19
A16-M1-B19
A17-M1-B19
A18-M1-B19
A04-M1-B19
A20-M1-B19
A21-M1-B19
A22-M1-B19
A23-M1-B19
A24-M1-B19
A25-M1-B19
A26-M1-B19
A02-M1-B20
A05-M1-B20
A06-M1-B20
A08-M1-B20
A10-M1-B20
A11-M1-B20
A12-M1-B20
A14-M1-B20
A15-M1-B20
A16-M1-B20
A17-M1-B20
A18-M1-B20
A04-M1-B20
A20-M1-B20
A21-M1-B20
A22-M1-B20
A23-M1-B20
A24-M1-B20
A25-M1-B20
A26-M1-B20
A02-M1-B21
A05-M1-B21
A06-M1-B21
A08-M1-B21
A10-M1-B21
A11-M1-B21
A12-M1-B21
A14-M1-B21
A15-M1-B21
A16-M1-B21
A17-M1-B21
A18-M1-B21
A04-M1-B21
A20-M1-B21
A21-M1-B21
A22-M1-B21
A23-M1-B21
A24-M1-B21
A25-M1-B21
A26-M1-B21
A02-M1-B22
A05-M1-B22
A06-M1-B22
A08-M1-B22
A10-M1-B22
A11-M1-B22
A12-M1-B22
A14-M1-B22
A15-M1-B22
A16-M1-B22
A17-M1-B22
A18-M1-B22
A04-M1-B22
A20-M1-B22
A21-M1-B22
A22-M1-B22
A23-M1-B22
A24-M1-B22
A25-M1-B22
A26-M1-B22
A02-M1-B23
A06-M1-B23
A08-M1-B23
A10-M1-B23
A11-M1-B23
A12-M1-B23
A14-M1-B23
A15-M1-B23
A16-M1-B23
A17-M1-B23
A18-M1-B23
A04-M1-B23
A20-M1-B23
A21-M1-B23
A22-M1-B23
A23-M1-B23
A24-M1-B23
A25-M1-B23
A26-M1-B23
A02-M1-B24
A05-M1-B24
A06-M1-B24
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A15-M1-B50
A16-M1-B50
A18-M1-B50
A04-M1-B50
A20-M1-B50
A21-M1-B50
A22-M1-B50
A23-M1-B50
A24-M1-B50
A25-M1-B50
A26-M1-B50
A02-M1-B51
A05-M1-B51
A06-M1-B51
A08-M1-B51
A10-M1-B51
A11-M1-B51
A12-M1-B51
A14-M1-B51
A15-M1-B51
A16-M1-B51
A17-M1-B51
A18-M1-B51
A04-M1-B51
A20-M1-B51
A21-M1-B51
A22-M1-B51
A23-M1-B51
A24-M1-B51
A25-M1-B51
A26-M1-B51
A02-M1-B52
A05-M1-B52
A06-M1-B52
A08-M1-B52
A10-M1-B52
A11-M1-B52
A12-M1-B52
A14-M1-B52
A16-M1-B52
A17-M1-B52
A04-M1-B52
A20-M1-B52
A20-M1-B52
A22-M1-B52
A23-M1-B52
A24-M1-B52
A25-M1-B52
A26-M1-B52
A02-M1-B53
A05-M1-B53
A06-M1-B53
A08-M1-B53
A10-M1-B53
A11-M1-B53
A12-M1-B53
A14-M1-B53
A16-M1-B53
A17-M1-B53
A18-M1-B53
A04-M1-B53
A20-M1-B53
A21-M1-B53
A22-M1-B53
A23-M1-B53
A24-M1-B53
A25-M1-B53
A26-M1-B53
A02-M1-B54
A06-M1-B54
A08-M1-B54
A10-M1-B54
A11-M1-B54
A12-M1-B54
A14-M1-B54
A17-M1-B54
A18-M1-B54
A04-M1-B54
A20-M1-B54
A22-M1-B54
A23-M1-B54
A24-M1-B54
A25-M1-B54
A26-M1-B54
A02-M1-B55
A06-M1-B55
A08-M1-B55
A10-M1-B55
A11-M1-B55
A12-M1-B55
A14-M1-B55
A04-M1-B55
A20-M1-B55
A21-M1-B55
A22-M1-B55
A23-M1-B55
A24-M1-B55
A25-M1-B55
A26-M1-B55
A20-M1-B56
A23-M1-B56
A24-M1-B56
A25-M1-B56
A26-M1-B56
A50-M2-B41
A51-M1-B41
A52-M1-B41
A53-M1-B41
A57-M2-B41
A60-M2-B41
A50-M2-B43
A50-M1-B43
A51-M1-B43
A52-M1-B43
A53-M1-B43
A55-M2-B43
A56-M2-B43
A57-M2-B43
A58-M2-B43
A59-M2-B43
A60-M2-B43
A61-M2-B43
A50-M1-B44
A50-M2-B44
A51-M1-B44
A52-M1-B44
A53-M1-B44
A55-M2-B44
A56-M2-B44
A59-M2-B44
A60-M2-B44
A50-M2-B45
A51-M1-B45
A52-M1-B45
A53-M1-B45
A55-M2-B45
A56-M2-B45
A59-M2-B45
A60-M2-B45
A62-M2-B45
A50-M1-B46
A50-M2-B46
A51-M1-B46
A52-M1-B46
A53-M1-B46
A55-M2-B46
A56-M2-B46
A57-M2-B46
A58-M2-B46
A59-M2-B46
A60-M2-B46
A61-M2-B46
A62-M2-B46
A30-M1-B47
A30-M2-B47
A50-M1-B47
A50-M2-B47
A51-M1-B47
A52-M1-B47
A53-M1-B47
A55-M2-B47
A56-M2-B47
A57-M2-B47
A58-M2-B47
A59-M2-B47
A60-M2-B47
A61-M2-B47
A62-M2-B47
A50-M2-B48
A51-M1-B48
A52-M1-B48
A53-M1-B48
A55-M2-B48
A56-M2-B48
A60-M2-B48
A51-M1-B50
A53-M1-B50
A51-M1-B51
A52-M1-B51
A53-M1-B51
A52-M1-B52
A53-M1-B52
A51-M1-B53
A52-M1-B53
A53-M1-B53
A53-M1-B54 and
A53-M1-B55.