Systems and methods for ion mobility control
The invention provides, in various embodiments, systems and methods relating to controlling ion behavior in an ion-based analysis system.
1. A system for controlling ion behavior in an ion mobility based analyzer comprising:
a flow path for providing a flow of ions,
an ion filter for generating an ion filter field in the flow path, the ion filter field for filtering the flow of ions by separating ions in the flow of ions according to species, the separating being based on ion-mobility-based behavior of the ions in the ion filter field, the ion filter including:
a substrate,
a first insulating layer in communication with a portion of the substrate,
a first pair of filter electrodes for generating a first portion of the filter field, the first pair of filter electrodes including first and second filter electrodes, at least one of the first and second filter electrodes being in communication with the first insulating layer,
a second pair of filter electrodes for generating a second portion of the filter field, the second pair of filter electrodes including third and fourth filter electrodes,
wherein the first and second pair of filter electrodes are biased to provide an influencing electric field to a portion of the flow path to propel the ions along the flow path substantially from the first pair of filter electrodes toward the second pair of filter electrodes.
2. The system of claim 1 , wherein the filter field includes an asymmetric field.
3. The system of claim 2 , wherein the first and second filter electrodes face each other across a portion of the flow path.
4. The system of claim 3 , wherein the second and third filter electrodes face each other across a portion of the flow path.
5. The system of claim 4 , wherein a portion of the substrate extends along a portion of the flow path from the first filter electrode to the third filter electrode.
6. The system of claim 1 , wherein at least one of the third and fourth filter electrodes are in communication with a second insulating layer.
7. The system of claim 6 , wherein the at least one of the first and second insulating layers include a partially-conductive material.
8. The system of claim 1 comprising a control electrode for dissipating a charge build up along a portion of the flow path.
9. The system of claim 1 comprising a guiding electrode for steering a portion of the ions into the ion filter field.
10. The system of claim 1 , wherein the guiding electrode includes one of a positive and negative potential.
11. A system for controlling ion behavior in an ion mobility based analyzer comprising:
a flow path for providing a flow of ions,
an ion filter for generating an ion filter field in the flow path, the ion filter field for filtering the flow of ions by separating ions in the flow of ions according to species, the separating being based on ion-mobility-based behavior of the ions in the ion filter field, the ion filter including:
a substrate,
an insulating layer in communication with a portion of the substrate,
a first pair of filter electrodes for generating a first portion of the filter field, the first pair of filter electrodes including first and second filter electrodes, at least one of the first and second filter electrodes being in communication with the insulating layer,
a second pair of filter electrodes for generating a second portion of the filter field, the second pair of filter electrodes including third and fourth filter electrodes,
wherein the first and second pair of filter electrodes are biased to provide an influencing electric field to a portion of the flow path to propel the ions along the flow path substantially from the first pair of filter electrodes toward the second pair of filter electrodes, and
a guiding electrode for steering a portion of the ions into the ion filter field.
12. The system of claim 11 , wherein the guiding electrode is biased either positively or negatively.
13. The system of claim 12 , wherein the bias provides an influencing field that at least partially propels ions into the ion filter field.
14. The system of claim 13 , wherein the guiding electrode propels ions of one of a positive and negative polarity into the ion filter field.
15. A system for controlling ion behavior in an ion mobility based analyzer comprising:
a flow path for providing a flow of ions,
an ion filter for separating ions based on ion-mobility-based behavior of the ions in an ion filter field and for providing a propulsive field for supporting the flow of ions, the ion filter including:
a substrate,
an insulating layer in communication with a portion of the substrate,
an array of filter electrode pairs, each filter electrode pair including first and second electrodes facing each other across the flow path, the array of filter electrodes being biased to provide the propulsive field, at least one filter electrode being in communication with the insulating layer, and
a guiding electrode for steering ions into the ion filter field.
16. The system of claim 15 comprising a detector for detecting a portion of the ions exiting the ion filter field.
17. The system of claim 16 comprising a guard electrode for inhibiting at least one filter electrode signal from interfering with the detector.
18. A method for controlling ion behavior in an ion mobility based analyzer comprising:
providing a flow of ions along a flow path,
separating ions based on ion-mobility-based behavior of the ions in an ion filter,
propelling ions through the ion filter based, at least in part, on a propulsive field,
providing a substrate to support the ion filter,
providing an insulating layer in communication with a portion of the substrate,
providing an array of filter electrode pairs, each filter electrode pair including first and second electrodes facing each other across the flow path, the array of filter electrodes being biased to provide the propulsive field, at least one filter electrode being in communication with the insulating layer, and
steering ions into the ion filter field using a guiding electrode.
19. The method of claim 18 comprising dissipating a charge buildup along a portion of the flow path.
20. The method of claim 18 comprising inhibiting one or more filter electrode signals from interfering with a detector signal using at least one guard electrode.
21. A system for controlling ion behavior in an ion mobility based analyzer comprising:
a gas chromatograph for providing an elution of ions,
a flow path for receiving the elution of ions and providing a flow of the ions,
an ion filter for separating the ions based on ion-mobility-based behavior of the ions in an ion filter field and for providing a propulsive field for supporting the flow of ions, the ion filter including:
a substrate,
an insulating layer in communication with the substrate,
an array of filter electrode pairs, each filter electrode pair including first and second electrodes facing each other across the flow path, the array of filter electrodes being biased to provide the propulsive field, and
a guiding electrode for steering ions into the ion filter field.
22. The system of claim 21 , wherein the ion filter is included in a chip assembly.
23. The system of claim 21 , wherein the insulating material includes semiconductor material.
24. The system of claim 21 , wherein the guiding electrode includes one of a positive and negative potential.
25. The system of claim 24 , wherein the guiding electrode propels one of positive and negative ions in the ion filter.