Fat regulation
The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.
1. A method for treating obesity in an obese subject, the method comprising administering to the subject an effective amount of a heterocyclic carbonyl glycine compound which inhibits a hypoxia inducible factor (HIF) hydroxylase, thereby treating the obesity in the subject.
2. A method for regulating body weight in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carbonyl glycine compound which inhibits a HIF hydroxylase, thereby regulating body weight in the subject.
3. A method for reducing body fat in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carbonyl glycine compound which inhibits a HIF hydroxylase, thereby reducing body fat in the subject.
4. The method of claim 3 , wherein the body fat is visceral fat.
5. The method of claim 3 , wherein the body fat is abdominal fat.
6. The method of any one of claims 1 , 2 , and 3 , wherein the HIF hydroxylase is a HIF prolyl hydroxylase.
7. The method of any one of claims 1 , 2 , and 3 , wherein the subject is a mammal.
8. The method of claim 7 , wherein the mammal is a human.
9. The method of any one of claims 1 , 2 , and 3 , wherein the compound is [(7-Chloro-3-hydroxy-quinoline-2-carbonyl)-amino]-acetic acid.
10. The method of any one of claims 1 , 2 , and 3 , wherein the compound is [(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-acetic acid.
11. The method of any one of claims 1 , 2 , and 3 , wherein the compound is [(4-Hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid.
12. The method of any one of claims 1 , 2 , and 3 , wherein the compound is 4-Oxo-1,4-dihydro-[1,10 ]phenanthroline-3 -carboxylic acid.
13. The method of any one of claims 1 , 2 , and 3 , wherein the compound is [(1-Chloro-4-hydroxy-7-methoxy-isoquinoline-3 -carbonyl)-amino]-acetic acid.
14. The method of any one of claims 1 , 2 , and 3 , wherein the compound is [(3-Hydroxy-6-isopropoxy-quinoline-2-carbonyl)-amino]-acetic acid.
15. The method of any one of claims 1 , 2 , and 3 , wherein the compound is [(3-Hydroxy-pyridine-2-carbonyl)-amino]-acetic acid.
16. The method of any one of claims 1 , 2 , and 3 , wherein the compound is [(7-Benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester.