Cross-linked glycopeptide-cephalosporin antibiotics
View Patent ↗This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
1. A lyophilized composition comprising:
(a) a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof and
(b) a pharmaceutically-acceptable carrier.
2. The lyophilized composition of claim 1 , wherein the pharmaceutically acceptable carrier is sucrose, mannitol, dextrose, dextran, lactose, or a combination thereof.
3. The lyophilized composition of claim 1 , wherein the pharmaceutically acceptable carrier is sucrose, mannitol, or a combination thereof.
4. The lyophilized composition of claim 1 , wherein the pharmaceutically acceptable carrier is sucrose.
5. The lyophilized composition of claim 1 , wherein the composition is sterile.
6. The lyophilized composition of claim 1 , wherein the compound is a hydrochloride salt.
7. An aqueous composition comprising:
(a) a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof
(b) a pharmaceutically-acceptable carrier; and
(c) water.
8. The aqueous composition of claim 7 , wherein the pharmaceutically acceptable carrier is sucrose, mannitol, dextrose, dextran, lactose, or a combination thereof.
9. The aqueous composition of claim 7 , wherein the pharmaceutically acceptable carrier is sucrose, mannitol, or a combination thereof.
10. The aqueous composition of claim 7 , wherein the pharmaceutically acceptable carrier is sucrose.
11. The aqueous composition of claim 7 , wherein the composition is sterile.
12. The aqueous composition of claim 7 , wherein the compound is a hydrochloride salt.