Wearable pulse wave velocity blood pressure sensor and methods of calibration thereof
An apparatus and methods for performing a circulatory measurement on an extremity, such as a hand, of a subject. The circulatory measurement results in the derivation of an output circulatory metric that may encompass blood pressure or various other circulatory metrics. An indicator of an input circulatory metric at a locus on the extremity is measured, such as a pulse transit time, and calibrated to account for the hydrostatic component of blood pressure arising due to vertical displacement of the extremity with respect to the heart.
1. A method for deriving an output circulatory metric at an extremity of a subject, the method comprising:
measuring a first plethysmographic signal at a first position on the extremity of the subject and measuring a second plethysmographic signal at a second position on the extremity of the subject, each of the signals being measured at a plurality of heights, by means of a sensor disposed on the extremity of the subject, the second position characterized by a distance between the first position and the second position;
establishing a functional relationship using a digital computer, the functional relationship based at least on the measurements of the first and second plethysmographic signals at the plurality of heights, the functional relationship providing a quantitative relationship between the first and second plethysmographic signals and the output circulatory metric absent a direct measurement of the output circulatory metric at each of the plurality of heights; and
calculating a transit time of a circulatory pressure wave based on the first and second plethysmographic signals;
deriving a wave speed based on the calculated transit time and the distance between the first and second positions; and
applying the functional relationship to derive the output circulatory metric.
2. The method of claim 1 , wherein the output circulatory metric is an arterial blood pressure of the subject.
3. The method of claim 2 , wherein the arterial blood pressure of the subject is at least one of systolic, diastolic, and mean arterial blood pressure.
4. The method of claim 1 , wherein the first position is at a wrist of the subject.
5. The method of claim 1 , wherein the first plethysmographic signal is based upon measurement of blood volume in an ulnar artery of the subject.
6. The method of claim 1 , wherein the first plethysmographic signal is based upon measurement of blood volume in a radial artery of the subject.
7. The method of claim 1 , wherein the second plethysmographic signal is based upon measurement of blood volume in a digit of the subject.
8. The method of claim 1 , wherein the step of measuring first and second plethysmographic signals include obtaining circulatory waveforms at the first and second positions on the extremity.
9. The method of claim 8 , further comprising identifying a point of comparison between the waveform of the first plethysmographic signal and the waveform of the second plethysmographic signal.
10. The method of claim 8 , wherein identifying a point of comparison includes defining a measure based on a specified fraction of the range between a maximum value of the waveform and a minimum value of the waveform.
11. The method of claim 1 , wherein the step of establishing a functional relationship includes identifying a response function of a sensor signal as a function of intra-arterial pressure.
12. The method of claim 11 , wherein the step of identifying a response function of the sensor signal as a function of intra-arterial pressure includes application of adaptive noise cancellation.
13. The method of claim 1 , further comprising identifying a value of pulse transit time at zero pressure that is independent of the output circulatory metric.
14. The method of claim 13 , further comprising measurement of a value related to a derivative of pulse velocity with respect to arterial pressure.