Glycopeptide phosphonate derivatives
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
1. A method for treating a bacterial infection in a human, the method comprising administering to the human a compound of the formula:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the compound is a hydrochloride salt.
3. The method of claim 1 , wherein the compound or a pharmaceutically acceptable salt thereof is administered intravenously.
4. The method of claim 1 , wherein the compound or a pharmaceutically acceptable salt thereof is administered once per day.
5. A method for treating a staphylococcal infection in a human, the method comprising administering to the human a compound of the formula:
or a pharmaceutically acceptable salt thereof.
6. The method of claim 5 , wherein the compound is a hydrochloride salt.
7. The method of claim 5 , wherein the compound or a pharmaceutically acceptable salt thereof is administered intravenously.
8. The method of claim 5 , wherein the compound or a pharmaceutically acceptable salt thereof is administered once per day.
9. The method of claim 5 , wherein the staphylococcal infection is caused by Staphylococcus aureus.
10. The method of claim 5 , wherein the staphylococcal infection is caused by methicillin-resistant Staphylococcus aureus.