Materials with covalently-bonded, nonleachable, polymeric antimicrobial surfaces
View Patent ↗This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.
1. An inherently antimicrobial composition comprising:
a. a substrate; and,
b. a coating, layer, or enhanced surface area on said substrate, consisting essentially of polymeric molecules formed by the polymerization of a diallyldialkylammonium salt wherein said polymeric molecules are non-leachably bound to said substrate, and wherein said coating, layer, or enhanced surface area exhibits antimicrobial activity due to the presence of said polymeric molecules.
2. The composition of claim 1 , wherein said diallyldialkylammonium salt is a diallyldimethylammonium salt.
3. The composition of claim 1 , wherein said composition comprises all or part of a wound dressing, a sanitary pad, a tampon, an intrinsically antimicrobial absorbent dressing, a diaper, toilet paper, a sponge, a sanitary wipe, a food preparation surface, a gown, a glove, a surgical scrub, a suture, a needle, a sterile packing, a floor mat, a lamp handle cover, a burn dressing, a gauze roll, a blood transfer tubing or storage container, a mattress cover, bedding, a sheet, a towel, underwear, a sock, a cotton swab, an applicator, an exam table cover, a head cover, a cast liner, a splint, a padding, a lab coat, an air filter for an auto, a plane, or an HVAC system, a military protective garment, a face mask, a device for protection against biohazards and biological warfare agents, lumber, meat packaging material, or paper currency.
4. The composition of claim 1 , wherein said substrate is comprised, in whole or in part, of cellulose, or other naturally-derived polymers.
5. The composition of claim 1 wherein said substrate is comprised, in whole or in part, of synthetic polymers including, but not limited to: polyethylene, polypropylene, nylon, polyester, polyurethane, or silicone.
6. The antimicrobial composition of claim 1 , wherein said substrate is a woven or nonwoven flexible matrix, and said composition is formed into the shape of a wound dressing.
7. The antimicrobial composition of claim 1 , wherein said composition absorbs aqueous liquids.
8. The antimicrobial composition of claim 1 , wherein said substrate is wood, lumber, or an extract comprising or a derivative of wood fiber.
9. The composition of claim 1 , wherein said polymeric molecules are formed by the polymerization of diallyldimethylammonium chloride, also known as DADMAC.
10. The composition of claim 1 , wherein said substrate is a woven fabric.
11. The composition of claim 1 , wherein said substrate is a nonwoven.
12. The composition of claim 1 , wherein the polymer is a homopolymer.
13. The inherently antimicrobial composition of claim 1 , wherein said substrate is a superabsorbent material.
14. The inherently antimicrobial composition of claim 13 wherein the superabsorbent material comprises a flexible substrate.
15. The inherently antimicrobial composition of claim 13 wherein said substrate is comprised, in whole or in part, of cellulose or other naturally-derived polymer.
16. The inherently antimicrobial composition of claim 13 wherein said substrate is comprised, in whole or in part, of a synthetic polymer.
17. The inherently antimicrobial composition of claim 13 , wherein said diallyldialkylammonium salt is a diallyldimethylammonium salt.
18. The inherently antimicrobial composition of claim 17 , wherein said diallyldimethylammonium salt is diallyldimethylammonium chloride, also known as DADMAC.
19. The inherently antimicrobial composition of claim 13 , wherein said composition comprises all or part of a wound dressing, a sanitary pad, a tampon, an intrinsically antimicrobial absorbent dressing, a diaper, toilet paper, a sponge, a sanitary wipe, a burn dressing, gauze roll, a mattress cover, bedding, a sheet a towel, underwear, a sock, a cotton swab, an applicators, an exam table cover, a head cover, a cast liner, a padding, a lab coat, an air filter for an auto, a plane, or an HVAC systems, a military protective garment, a face mask, a device for protection against biohazards and biological warfare agents, meat packaging material, or paper currency.
20. An antimicrobial-coated composition for destruction of microbes contacting said composition, comprising:
a. a substrate onto which a coating of antimicrobial polymers is bonded; and,
b. said coating, formed of an antimicrobially effective amount of polymeric molecules formed by the polymerization of diallyldimethylammonium chloride, also known as DADMAC, wherein said polymeric molecules are non-leachably and covalently bonded to surface sites of said substrate, and wherein said composition is absorbent of aqueous liquids, whereby said polymeric molecules act to destroy microbes coming in contact with said polymeric molecules.