IP Library Granted Patent US 7,715,921
Granted Patent B2
US 7,715,921 · App. 11/294,780 · Granted May 11, 2010

Electrodes for applying an electric field in-vivo over an extended period of time

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Quick Facts
Patent No.
US 7,715,921
App. No.
11/294,780
Granted
May 11, 2010
Kind
B2
Abstract

As compared to conventional electrodes, the electrode configurations disclosed herein minimize irritation and damage to the skin when they are placed in contact with a patient's body over extended of time. The electrodes are formed from a conductive substrate coated with a thin dielectric material, and a plurality of open spaces pass through the electrodes. Those open spaces are distributed and sized to permit moisture on the surface of the patient's body to escape when the electrode is placed in contact with the patient's body. One intended use for the electrodes is for treating tumors by applying an AC electric field with specific frequency and field strength characteristics over an extended period of time.

Claims (13)

1. An electrode configured for placement in contact with a surface of a patient's body, the electrode comprising:

a conductive substrate having a first side that faces the patient when the electrode is placed in contact with the patient's body, the conductive substrate having a plurality of open spaces passing therethrough that pass through the first side of the conductive substrate, wherein the open spaces are distributed and sized to permit moisture on the surface of the patient's body to escape via the open spaces when the electrode is placed in contact with the patient's body; and

a thin dielectric material disposed on the first side of the conductive substrate so as to insulate the conductive substrate from the patient's body when the electrode is placed in contact with the patient's body, wherein the dielectric coating has a dielectric constant of at least 1000.

2. The electrode of claim 1 , wherein the conductive substrate is a single piece of conductive material.

3. The electrode of claim 1 , wherein the conductive substrate comprises a plurality of separate sections that are attached to one another in a manner that permits the sections to move with respect to neighboring sections, by a limited amount.

4. The electrode of claim 1 , wherein the conductive substrate comprises a plurality of roughly parallel wires spaced apart by at least 2 mm, and wherein the thin dielectric material surrounds each of the wires.

5. The electrode of claim 1 , wherein the open spaces are at least 2 mm wide.

6. The electrode of claim 1 , wherein the open spaces are at least 4 mm wide.

7. The electrode of claim 1 , wherein the open spaces have an area that is least 4 square mm.

8. The electrode of claim 1 , wherein the open spaces have an area that is least 16 square mm.

9. The electrode of claim 1 , wherein the open spaces are arranged in a pattern that permits portions of the surface of a patient's body that are covered when the electrode is in the first position to become uncovered when the electrode is moved to a second position, with the overall footprint of the electrode in the first position substantially overlapping the overall footprint of the electrode in the second position.

10. The electrode of claim 9 , wherein the combined area of all the open spaces is roughly half the area of the footprint of the electrode.

11. The electrode of claim 1 , wherein the dielectric coating has a dielectric constant of at least 10,000.

Assignments (18)
PATENT SECURITY AGREEMENT Recorded May 4, 2024
From: NOVOCURE GMBH (SWITZERLAND)
To: BIOPHARMA CREDIT PLC
Reel/Frame 067315/0399 →
RELEASE OF SECURITY INTEREST Recorded Apr 24, 2024
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: NOVOCURE GMBH
Reel/Frame 067211/0839 →
SECURITY INTEREST Recorded Nov 6, 2020
From: NOVOCURE GMBH
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 054344/0510 →
RELEASE OF SECURITY INTEREST FOR PATENT SECURITY AGREEMENT FILED AT REEL/FRAME 45278 0825 Recorded Aug 25, 2020
From: BIOPHARMA CREDIT PLC
To: NOVOCURE LIMITED
Reel/Frame 053597/0335 →
RELEASE OF SECURITY INTEREST FOR PATENT SECURITY AGREEMENT FILED AT REEL/FRAME 50395/0398 Recorded Aug 19, 2020
From: BPCR LIMITED PARTNERSHIP
To: NOVOCURE GMBH
Reel/Frame 053538/0623 →
OMNIBUS CONFIRMATION OF ASSIGNMENT AGREEMENT Recorded May 21, 2020
From: BIOPHARMA CREDIT PLC
To: BPCR LIMITED PARTNERSHIP
Reel/Frame 052741/0173 →
RELEASE OF SECURITY INTEREST FOR PATENT SECURITY AGREEMENT FILED AT REEL/FRAME 045278/0825 Recorded Apr 14, 2020
From: BIOPHARMA CREDIT PLC
To: NOVOCURE LIMITED
Reel/Frame 052391/0549 →
RELEASE OF SECURITY INTEREST Recorded Apr 13, 2020
From: BIOPHARMA CREDIT PLC
To: NOVOCURE LIMITED
Reel/Frame 052383/0705 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 20, 2019
From: NOVOCURE LIMITED
To: NOVOCURE GMBH
Reel/Frame 050110/0098 →
SECURITY INTEREST Recorded May 6, 2019
From: NOVOCURE GMBH
To: BIOPHARMA CREDIT PLC
Reel/Frame 050395/0398 →
SECURITY INTEREST Recorded Feb 7, 2018
From: NOVOCURE LIMITED
To: BIOPHARMA CREDIT PLC
Reel/Frame 045284/0851 →
RELEASE OF SECURITY INTEREST Recorded Feb 7, 2018
From: BIOPHARMA SECURED INVESTMENTS III HOLDINGS CAYMAN LP
To: NOVOCURE LIMITED
Reel/Frame 044858/0416 →
SECURITY INTEREST Recorded Feb 7, 2018
From: NOVOCURE LIMITED
To: BIOPHARMA CREDIT PLC
Reel/Frame 045278/0825 →
SECURITY INTEREST Recorded Feb 2, 2015
From: NOVOCURE LIMITED
To: BIOPHARMA SECURED INVESTMENTS III HOLDINGS CAYMAN LP
Reel/Frame 034866/0402 →
RELEASE OF SECURITY INTEREST Recorded Dec 20, 2013
From: DEUTSCHE BANK TRUST COMPANY AMERICAS
To: NOVOCURE LIMITED
Reel/Frame 031866/0567 →
SECURITY AGREEMENT Recorded Feb 20, 2013
From: NOVOCURE LIMITED
To: DEUTSCHE BANK TRUST COMPANY AMERICAS
Reel/Frame 029845/0135 →
CHANGE OF NAME Recorded May 19, 2011
From: STANDEN LIMITED
To: NOVOCURE LIMITED
Reel/Frame 026311/0210 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 12, 2008
From: PALTI, YORAM
To: STANDEN LTD.
Reel/Frame 020934/0274 →