Inhibition of bid-induced cell-death using small organic molecules
Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.
1. A compound having the formula (A):
wherein each of R 1 and R 2 is independently selected from a group consisting of:
Y is a moiety selected from a group consisting of:
X is a moiety selected from a group consisting of:
R 3 is at least one substitutent in ortho-, meta-, or para-position of the benzene ring, wherein “(R 3 ) 1-5 ” symbolizes that the number of R 3 substitutents is between 1 and 5, inclusively, wherein R 3 is selected from a group consisting of:
n is an integer having the value between 1 and 5; and
Ph in any of R 1 , R 2 , and R 3 is independently selected from an unsubstituted phenyl ring and a substituted phenyl ring having between one and five substitutents in ortho-, meta-, or para-position of the benzene ring, wherein the substitutents in the ring are selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , having the formula (I):
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , having the formula II
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , having the formula III
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , having the formula IV
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , having the formula V
or a pharmaceutically acceptable salt thereof.
7. A compound having the formula C:
wherein each of R 1 and R 2 is independently selected from a group consisting of:
Y is a moiety selected from a group consisting of:
X is a moiety selected from a group consisting of:
R 3 is at least one substitutent in ortho-, meta-, or para-position of the benzene ring, wherein “(R 3 ) 1-5” symbolizes that the number of R 3 substitutents is between 1 and 5, inclusively, wherein R 3 is selected from a group consisting of:
n is an integer having the value between 1 and 5; and
Ph in any of R 1 , R 2 , and R 3 is independently selected from an unsubstituted phenyl ring and a substituted phenyl ring having between one and five substitutents in ortho-, meta-, or para-position of the benzene ring, wherein the substitutents in the ring are selected from the group consisting of:
8. A pharmaceutical composition comprising at least one compound of claim 1 or 7 , and a pharmaceutically acceptable carrier therefor.