Compounds for targeting endothelial cells, compositions containing the same and methods for their use
View Patent ↗The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
1. A method of imaging endothelial cells, tumor cells or other cells that express NP-1 in a human or animal comprising:
a) administering to said human or animal a composition comprising a compound of the formula (I)
A-L-B (I)
in which:
A is a monomer of TKPPR (SEQ ID NO:2) or a monomer of a TKPPR (SEQ ID NO:2) analogue which contains TKPPR (SEQ ID NO:2) and which
specifically binds to NP-1 or cells which express NP-1 with avidity that is equal to or greater than TKPPR (SEQ ID NO:2);
L is a linker; and
B is a phospholipid; and
b) detecting said compound.
2. The method of claim 1 wherein a tumor in a human or an animal is staged.