IP Library Granted Patent US 7,820,621
Granted Patent B2
US 7,820,621 · App. 11/381,884 · Granted Oct 26, 2010

Compounds for targeting endothelial cells, compositions containing the same and methods for their use

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Quick Facts
Patent No.
US 7,820,621
App. No.
11/381,884
Granted
Oct 26, 2010
Kind
B2
Abstract

The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.

Claims (10)

1. A method of imaging endothelial cells, tumor cells or other cells that express NP-1 in a human or animal comprising:

a) administering to said human or animal a composition comprising a compound of the formula (I)

A-L-B  (I)

in which:

A is a monomer of TKPPR (SEQ ID NO:2) or a monomer of a TKPPR (SEQ ID NO:2) analogue which contains TKPPR (SEQ ID NO:2) and which

specifically binds to NP-1 or cells which express NP-1 with avidity that is equal to or greater than TKPPR (SEQ ID NO:2);

L is a linker; and

B is a phospholipid; and

b) detecting said compound.

2. The method of claim 1 wherein a tumor in a human or an animal is staged.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 15, 2010
From: BRACCO INTERNATIONAL B.V.
To: BRACCO SUISSE SA
Reel/Frame 024990/0087 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2010
From: YAN, FENG; SCHNEIDER, MICHEL
To: BRACCO INTERNATIONAL B.V.
Reel/Frame 023807/0842 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 9, 2007
From: VON WRONSKI, MATHEW A.; MARINELLI, EDMUND R.; NUNN, ADRIAN D.; PILLAI, RADHAKRISHNA; RAMALINGAM, KONDAREDDIAR; TWEEDLE, MICHAEL F.; LINDER, KAREN E.; NANJAPPAN, PALANIAPPA; RAJU, NATARAJAN
To: BRACCO RESEARCH USA
Reel/Frame 019673/0694 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 9, 2007
From: BRACCO RESEARCH USA
To: BRACCO INTERNATIONAL BV
Reel/Frame 019673/0704 →