Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
The present invention relates to a drug-containing polymeric composition comprising at least one therapeutic agent encapsulated in at least one biocompatible polymer, wherein at least a portion of the therapeutic agent in this polymeric composition is crystalline. The at least one biocompatible polymer may form a substantially continuous polymeric matrix with the at least one therapeutic agent encapsulated therein. Alternatively, the at least one biocompatible polymer may form polymeric particles with the at least one therapeutic agent encapsulated therein.
1. A drug-containing polymeric composition comprising rapamycin in crystalline form encapsulated in at least one biocompatible polymer, wherein at least 95 percent of the rapamycin in said composition is crystalline, the crystals being in the range from about 100 nanometers to about 200 nanometers.