Inhibition of COX-2 and/or 5-LOX activity by fractions isolated or derived from hops
View Patent ↗A natural formulation of compounds isolated or derived from hops which inhibit the activity of cyclooxygenase-2 (COX-2) and/or 5-lipoxygenase (5-LOX) is disclosed. The hops formulations may be administered to a mammal to treat or inhibit a pathological condition associated with the activity of COX-2 and/or 5-LOX in such a mammal.
1. A method of treating an inflammatory condition in a mammal in need thereof, the method comprising administering to the mammal in need thereof a composition comprising a therapeutically effective amount of a compound selected from the group consisting of dihydro-isohumulone, dihydro-isocohumulone, dihydro-isoadhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-isoadhumulone, hexahydro-isohumulone, hexahydro-isocohumulone and hexahydro-isoadhumulone.
2. The method of claim 1 , wherein the compound is derived from hops.
3. The method of claim 1 , wherein the inflammatory condition is cancer.
4. The method of claim 3 , wherein the cancer is breast cancer.
5. The method of claim 3 , wherein the cancer is prostate cancer.
6. The method of claim 3 , wherein the cancer is colon cancer.
7. The method of claim 3 , wherein the cancer is pancreatic cancer.
8. The method of claim 1 , wherein the inflammatory condition is asthma.
9. The method of claim 1 , wherein the inflammatory condition is Alzheimer's Disease.
10. The method of claim 1 , wherein the inflammatory condition is arthritis.
11. The method of claim 1 , wherein the inflammatory condition is Crohn's Disease.
12. The method of claim 1 , wherein the inflammatory condition is eczema.
13. The method of claim 1 , wherein the inflammatory condition is Inflammatory Bowel Disease.
14. The method of claim 1 , wherein the inflammatory condition is osteoarthritis.
15. The method of claim 1 , wherein the inflammatory condition is psoriasis.