IP Library › Granted Patent US 7,951,377
Granted Patent B2
US 7,951,377 · App. 12/192,015 · Granted May 31, 2011

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

Assignees: Los Alamos National Security, LLC; Duke University; Beth Isreal Deaconess Medical Center; The University of Albama at Birmingham Research Foundation
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Quick Facts
Patent No.
US 7,951,377
App. No.
12/192,015
Granted
May 31, 2011
Kind
B2
Abstract

The present invention relates to mosaic clade M HIV-1 Env polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Claims (6)

1. An isolated and purified mosaic clade M human immunodeficiency virus type 1 (HIV-1) Env polypeptide comprising an amino acid sequence selected from the group consisting of M_mos_Env — 3 — 1 (SEQ ID NO:177), M_mos_Env — 3 — 2 (SEQ ID NO:178) and M_mos_Env — 3 — 3 (SEQ ID NO:179).

2. The polypeptide according to claim 1 wherein said polypeptide comprises the amino acid of SEQ ID NO:177.

3. The polypeptide according to claim 1 wherein said polypeptide comprises the amino acid of SEQ ID NO:178.

4. The polypeptide according to claim 1 wherein said polypeptide comprises the amino acid of SEQ ID NO:179.

5. A composition comprising the polypeptide according to claim 1 and a carrier.

6. A method of inducing an immune response against HIV-1 in a host comprising administering to said host an amount of the polypeptide according to claim 1 sufficient to induce said response.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2018
From: LOS ALAMOS NATIONAL SECURITY, LLC
To: TRIAD NATIONAL SECURITY, LLC
Reel/Frame 047485/0173 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2009
From: LIAO, HUA-XIN; HAYNES, BARTON F.
To: DUKE UNIVERSITY
Reel/Frame 022490/0180 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2009
From: LETVIN, NORMAN
To: BETH ISRAEL DEACONESS MEDICAL CENTER
Reel/Frame 022490/0183 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2009
From: KORBER, BETTE T.; FISCHER, WILLIAM
To: LOS ALAMOS NATIONAL SECURITY, LLC
Reel/Frame 022490/0557 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2009
From: HAHN, BEATRICE H.
To: UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION, THE
Reel/Frame 022490/0634 →
CONFIRMATORY LICENSE Recorded Jan 23, 2009
From: LOS ALAMOS NATIONAL SECURITY
To: ENERGY, U.S. DEPARTMENT OF
Reel/Frame 022153/0639 →
Continuity (4)
Continuation In Part 11990222
Provisional Application 60710154 · Aug 23, 2005
Provisional Application 60739413 · Nov 25, 2005
Related Publication 20090198042A1 · Aug 6, 2009