Macromer composition including light activated initiator
View Patent ↗The invention provides compositions that include macromers and visible light-activated polymerization initiators, and methods for forming a matrix using these compositions in conjunction with a light source that emits light primarily in the visible light spectrum.
1. A method for forming a matrix in situ in a periodontal procedure, comprising the steps of (a) applying a matrix-forming periodontal composition to a tissue in the oral cavity, the composition comprising (i) a macromer comprising a polysaccharide and (ii) a water-soluble diketone photoinitiator having an activation wavelength of 400 nm or greater; and (b) treating the composition to activate the diketone photoinitiator and promote formation of a matrix.
2. The method of claim 1 wherein the diketone photoinitiator has an activation wavelength in the range of 440 nm to 500 mm.
3. The method of claim 2 wherein the diketone photoinitiator is water-soluble camphorquinone.
4. The method of claim 1 wherein the macromer comprises hyaluronic acid.
5. The method of claim 1 wherein the macromer is present at a concentration in the range of 50 mg/mL to 100 mg/mL.
6. The method of claim 1 wherein the composition has a viscosity of about 500 cP or greater.
7. The method of claim 1 wherein the composition comprises a peroxide or hydroperoxide co-initiator.
8. The method of claim 1 wherein the composition comprises an alkyl hydroperoxide co-initiator.
9. The method of claim 7 wherein the co-initiator is present at a concentration of 7 mg/mL or greater.
10. The method of claim 1 wherein step (b) comprises activating the diketone photoinitiator with a visible-light emitting source selected from the group consisting of plasma arc sources, conventional halogen lamps, fast halogen lamps, and LEDs.
11. The method of claim 1 wherein the composition comprises a bioactive agent.
12. The method of claim 11 wherein the bioactive agent comprises a bioactive peptide.
13. The method of claim 12 , wherein the bioactive peptide comprises a bioactive collagen peptide.
14. The method of claim 1 , wherein the composition comprises filler particles.
15. The method of claim 1 , wherein the composition does not include a tertiary amine co-initiator.
16. The method of claim 1 , wherein the macromer has a molecular weight of 1×10 5 Da or greater.
17. A polymerizable composition for in situ use comprising a macromer, comprising a polysaccharide and a water-soluble diketone polymerization photoinitiator having an activation wavelength of greater than 400 nm, wherein the composition has a viscosity of 500 cP or greater.
18. A method for providing a matrix in situ comprising the steps of (a) providing a matrix-forming composition to a surface, the composition including a (i) macromer comprising a polysaccharide and (ii) a water soluble visible light activated diketone photoinitiator, and (b) activating the photoinitiator to promote formation of the matrix with a LED source having a peak emission wavelength of greater than 400 nm.
19. The method of claim 1 wherein the diketone photoinitiator comprises a charged group.
20. The method of claim 3 wherein the diketone photoinitiator is camphorquinone-10-sulfonic acid.
21. The polymerizable composition of claim 17 wherein the diketone photoinitiator is camphorquinone-10-sulfonic acid.