Methods for treating meibomian gland dysfunction employing fluid jet
According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.
1. A method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice comprising:
a) selecting a device capable of delivering a jet of heated medium;
b) positioning the device such that when the jet is delivered it is applied to the exterior surface of a closed eyelid, proximate to the gland channel orifice;
c) applying a jet of heated medium to the exterior surface of the closed eyelid proximate to the gland at a pressure of from about 2 psi to about 30 psi;
d) maintaining application of the jet of heated medium to the closed eyelid for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed.
2. A method according to claim 1 wherein the jet is applied in a pulsatory manner.
3. A method according to claim 1 wherein the jet is applied at a frequency between 1 Hz and 300 Hz.
4. A method according to claim 1 wherein the jet is applied at a frequency between 5 Hz and 60 Hz.
5. A method according to claim 1 wherein the heated medium is applied at a temperature of at least 42° C.
6. A method according to claim 1 wherein the device is positioned by attaching the device to the mammal.
7. A method according to claim 1 wherein the device is positioned by manually holding the device.
8. A method according to claim 1 wherein the jet may be repositioned during application of the jet.
9. A method according to claim 1 wherein the jet may not be repositioned during application of the jet.
10. A method according to claim 1 wherein the jet is applied to the exterior surface of the closed eyelid through an intervening membrane.
11. A method according to claim 1 wherein the jet is directly applied to the exterior surface of the closed eyelid.
12. A method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice comprising:
a) selecting a device capable of delivering a jet of heated medium;
b) positioning the device such that when the jet is delivered it is applied to the exterior surface of a closed eyelid, proximate to the gland channel orifice;
c) applying a jet of heated medium to the exterior surface of the closed eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi;
d) intermittently maintaining application of the jet of heated medium to the closed eyelid for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed.
13. A method according to claim 12 wherein the jet is applied in a pulsatory manner.
14. A method according to claim 13 wherein the jet is applied at a frequency of between 1 Hz and 300 Hz.
15. A method according to claim 13 wherein the jet is applied at a frequency of between 5 Hz and 60 Hz.
16. A method according to claim 12 wherein the heated medium is applied at a temperature of at least 42° C.
17. A method according to claim 12 wherein the device is positioned by attaching the device to the mammal.
18. A method according to claim 12 wherein the device is positioned by manually holding the device.
19. A method according to claim 12 wherein the jet may be repositioned during application of the jet.
20. A method according to claim 12 wherein the jet may not be repositioned during application of the jet.
21. A method according to claim 12 wherein the jet is indirectly applied to the exterior surface of the closed eyelid through an intervening membrane.
22. A method according to claim 12 wherein the jet is directly applied to the exterior surface of the closed eyelid.
23. The method according to claim 12 wherein jet is heated by the modalities selected from the group consisting of conduction, convection and radiation.
24. The method according to claim 12 wherein the jet is applied to the meibomian gland in a manner that milkingly moves up the meibomian gland channel from the end opposite the meibomian gland orifice toward the gland orifice.
25. The method according to claim 12 wherein the jet is selected from the group consisting of fluid, gas, and flowable creams.
26. The method according to claim 12 further including the step of positioning a protective membrane over the eye and applying the jet of the heated medium to the membrane such that the jet pressure is transmitted there through and is absorbed by the closed eyelid.
27. The method according to claim 26 wherein the jet is pulsatory.