Benzene sulfonamide thiazole and oxazole compounds
The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
1. A compound of formula
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition, comprising a compound of claim 1 , together with one or more of pharmaceutically acceptable carriers, diluents or excipients.
3. A pharmaceutical composition as claimed in claim 2 in unit dosage form.
4. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 1 .
5. The method of claim 4 , wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.
6. A compound of formula
7. A pharmaceutical composition, comprising a compound of claim 6 , together with one or more of pharmaceutically acceptable carriers, diluents or excipients.
8. A pharmaceutical composition as claimed in claim 7 in unit dosage form.
9. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 6 .
10. The method of claim 9 , wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.
11. A pharmaceutically acceptable salt of the compound of formula
12. A pharmaceutical composition, comprising a compound of claim 11 , together with one or more of pharmaceutically acceptable carriers, diluents or excipients.
13. A pharmaceutical composition as claimed in claim 12 in unit dosage form.
14. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 11 .
15. The method of claim 14 , wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.
16. N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide mesylate.
17. A pharmaceutical composition, comprising a compound of claim 16 , together with one or more of pharmaceutically acceptable carriers, diluents or excipients.
18. A pharmaceutical composition as claimed in claim 16 in unit dosage form.
19. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 16 .
20. The method of claim 19 , wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution.