Mammalian receptor protein DCRS5; methods of treatment
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
1. A method of treating a human subject experiencing an inflammatory bowel disorder (IBD) comprising administering an effective amount of an antagonist antibody that specifically binds to a polypeptide comprising residues 1-606 of SEQ ID NO: 2, or an antigen binding fragment.
2. The method of claim 1 , wherein the IBD is Crohn's disease.
3. The method of claim 2 , wherein the antibody or antigen binding fragment thereof comprises a monoclonal antibody or antigen binding fragment thereof.
4. The method of claim 2 , wherein the antibody or antigen binding fragment thereof comprises a humanized antibody or antigen binding fragment thereof.
5. The method of claim 2 , wherein the antibody or antigen binding fragment thereof comprises an Fab, Fv, or F(ab′) 2 fragment.
6. The method of claim 1 , wherein the IBD is ulcerative colitis.
7. The method of claim 6 , wherein the antibody or antigen binding fragment thereof comprises a monoclonal antibody or antigen binding fragment thereof.
8. The method of claim 6 , wherein the antibody or antigen binding fragment thereof comprises a humanized antibody or antigen binding fragment thereof.
9. The method of claim 6 , wherein the antibody or antigen binding fragment thereof comprises an Fab, Fv, or F(ab′) 2 fragment.