Modulating apoptosis
The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-κB activity. The modulators may be used, for example, in the treatment of NF-κB-mediated diseases, conditions, and injuries.
1. A method of treating apoptosis-mediated tissue damage in a subject, the method comprising administering to a subject in need thereof a composition comprising flagellin, wherein the apoptosis is attributable to cellular stress.
2. The method of claim 1 wherein the composition is administered prior to, together with, or after the tissue damage.
3. The method of claim 1 , wherein the cellular stress is radiation, and wherein the composition is administered in combination with a radioprotectant.
4. The method of claim 3 wherein the radioprotectant is an antioxidant.
5. The method of claim 4 wherein the antioxidant is selected from the group consisting of amifostine and vitamin E.
6. The method of claim 3 , wherein the radioprotectant is a cytokine.
7. The method of claim 6 , wherein the cytokine is stem cell factor.