Macro-diacrylates and macro-polacrylates
View Patent ↗The invention relates to covalent polymer networks composed of macro-diacrylates and polyacrylates having shape memory properties and that can be used in medical technology.
1. A covalent polymer network with shape memory properties comprising at least one cross-linked macro-polyacrylate, wherein said macro-polyacrylate comprises at least two acrylate groups and, includes both ester structural units and urethane structural units,
wherein said macro-polyacrylate has the general Formula (I):
wherein R 1 is a substituent of a macro-diol, R 2 is a substituent at least one of a low-molecular-weight diisocyanate, R 3 is at least one of hydrogen and a branched or unbranched alkyl group having from 1 to 4 carbon atoms, R 4 is at least one of a branched or unbranched alkylene group having from 2 to 10 carbon atoms and m is 0 or an integer in the range from 1 to 10, or
wherein said macro-polyacrylate has the general Formula (II):
wherein R 1 is a substituent of a macro-polyol, R 3 is at least one of a hydrogen and a lower alkyl, R 5 is at least one of a branched or unbranched alkylene group having from 2 to 10 carbon atoms and n is an integer of 2 or greater.
2. The covalent polymer network of claim 1 , wherein said macro-polyacrylate comprises 2 to 10 acrylate groups.
3. The covalent polymer network of claim 2 , wherein said macro-polyacrylate comprises 2 to 4 acrylate groups.
4. The covalent polymer network of claim 3 , wherein said macro-polyacrylate comprises 2 acrylate groups.
5. The covalent polymer network of claim 1 , wherein said macro-polyacrylate has the general formula (IIa):
wherein R 1 , R 3 and R 5 have the same meaning as defined for formula (II).
6. The covalent polymer network of claim 1 , wherein said diacrylate derives from a hydroxyalkyl methacrylate.
7. The covalent polymer network of claim 1 , wherein said macro-polyacrylate further comprises a structural unit of polyester polyols that are prepared by at least one of a ring opening polymerization of cyclic lactones and by polycondensation of polycarboxylic acid, polyhydroxycarboxylic acid, hydroxy polycarboxylic acid, or polyhydroxy polycarboxylic acid and polyhydroxy compounds.
8. The covalent polymer network of claim 1 , wherein said macro-polyacrylate has an average molecular weight (M n ) from 1,000 to 50,000.
9. The covalent polymer network of claim 1 , wherein said covalent polymer network is degradable.
10. The covalent polymer network of claim 1 , wherein the network is biocompatible.
11. An article for use in the medical field comprising the covalent polymer networks of claim 1 .
12. The article of claim 11 , wherein the article is an implant material for vascular or non-vascular applications.
13. The covalent polymer network of claim 1 , wherein said macro-diol or macro-polydiol is selected from diols and polyols of polyesters, diols and polyols of polyethers, and diols and polyols of polycarbonates.