Recombinant vaccines and use thereof
The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In particular, said invention relates to fusion molecules, comprising an antigen and the transmembrane region and cytoplasmic region of a MHC molecule and/or the cytoplasmic region of a MHC or a SNARE molecule.
1. An isolated fusion protein which comprises an antigen, a transmembrane region and a cytoplasmic region of an MHC molecule, and has the amino acid residue sequence of SEQ ID NO: 12.
2. The fusion protein of claim 1 additionally comprising a leader sequence.
3. The fusion protein of claim 2 wherein the leader sequence is derived from a MHC molecule.
4. The fusion protein of claim 2 wherein the fusion protein has the following arrangement of segments: N-terminus-leader sequence/antigen/transmembrane region/cytoplasmic region-C-terminus.