Vitamin D analogs for obesity prevention and treatment
Methods for treating and preventing obesity, inhibiting adipocyte differentiation, inhibiting increased SCD-1 gene transcription, and/or reducing body fat in a subject include administering at least one analog of 1α,25-dihydroxyvitamin D 3 or 1α,25-dihydroxyvitamin D 2 or a pharmaceutical composition that includes such an analog to a subject in need thereof. The analog may be a 19-nor vitamin D analog such as a compound of formula IA, a compound of formula IB, or a mixture thereof where the variables R 1 , R 2 , and R 3 have the values described herein.
1. A method for inhibiting adipocyte differentiation, inhibiting SCD-1 gene transcription, and/or reducing body fat in an animal subject in need thereof, comprising administering to the animal subject, an effective amount of a 19-nor vitamin D compound or a pharmaceutical composition comprising the compound, wherein the compound administered to the subject inhibits adipocyte differentiation, inhibits SCD-1 gene transcription, and/or reduces body fat in the animal subject, and further wherein the compound is selected from a compound of formula IID, a compound of formula IIE, a compound of formula IIF, a compound of formula IIG, a compound of formula IIH, a compound of formula IIJ, a compound of formula IIK, a compound of formula IIL, a compound of formula IIM, a compound of formula IIN, a compound of formula IIO, a compound of formula IIP, a compound of formula IIQ,
or is a combination thereof.
2. The method of claim 1 , wherein the compound has the formula IID
3. The method of claim 1 , wherein the compound has the formula IIE
4. The method of claim 1 , wherein the compound has the formula IIF
5. The method of claim 1 , wherein the compound has the formula IIG
6. The method of claim 1 , wherein the compound has the formula IIH
7. The method of claim 1 , wherein the compound has the formula IIJ
8. The method of claim 1 , wherein the compound has the formula IIK
9. The method of claim 1 , wherein the compound has the formula IIL
10. The method of claim 1 , wherein the compound has the formula IIM
11. The method of claim 1 , wherein the compound has the formula IIN
12. The method of claim 1 , wherein the compound has the formula IIO
13. The method of claim 1 , wherein the compound has the formula IIP
14. The method of claim 1 , wherein the compound has the formula IIQ