Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy) phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.
1. A composition comprising KX2-391 mesylate salt.
2. The composition of claim 1 , wherein the KX2-391 mesylate salt has a purity greater than 98.0% as determined by HPLC.
3. The composition of claim 1 , wherein the KX2-391 mesylate salt has a purity of 99.0%.
4. The composition of claim 1 , wherein the KX2-391 mesylate salt has a purity of 99.5%.
5. The composition of claim 1 , wherein the KX2-391 mesylate salt has a purity of 99.6%.
6. The composition of claim 1 , wherein the KX2-391 mesylate salt has a purity of 99.7%.
7. The composition of claim 1 , wherein the composition contains less than 2% of an impurity selected from ethyl chloride, ethanol, ethyl acetate, heptane, anisole, palladium, and combinations thereof.
8. The composition of claim 1 further comprising a pharmaceutically acceptable carrier or excipient.
9. A method of treating a disease or disorder in a subject in need thereof comprising administering a composition of claim 1 to said subject, wherein the disease or disorder is selected from colon cancer, lung cancer, prostate cancer, breast cancer, brain cancer, and psoriases.
10. The method of claim 9 , wherein the composition is administered orally.
11. The method of claim 9 , wherein the composition is administered topically.