Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof
The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R′ represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R″ represent a hydrogen atom.
1. A compound or pharmaceutically acceptable salt, which is selected from the group consisting of:
(a) a compound of formula:
(b) a pharmaceutically acceptable salt of a compound of formula:
(c) a compound of formula:
(d) a pharmaceutically acceptable salt of a compound of formula:
(e) a compound of formula:
and
(f) a pharmaceutically acceptable salt of a compound of formula:
2. A fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 1 , which is a fused polycyclic compound of formula:
or a pharmaceutically acceptable salt thereof.
3. A fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 1 , which is a fused polycyclic compound of formula:
or a pharmaceutically acceptable salt thereof.
4. A fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 1 , which is a fused polycyclic compound of formula:
or a pharmaceutically acceptable salt thereof.
5. A method for increasing the sugar-transporting capacity, comprising administering an effective amount of a fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 2 to a subject in need thereof.
6. A method for treating hypoglycemia, comprising administering an effective amount of a fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 2 to a subject in need thereof.
7. A method for treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance, or obesity, comprising administering an effective amount of a fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 2 to a subject in need thereof.
8. A pharmaceutical composition which comprises a fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 2 and a pharmaceutically acceptable carrier.
9. A method for increasing the sugar-transporting capacity, comprising administering an effective amount of a compound or pharmaceutically acceptable salt according to claim 1 to a subject in need thereof.
10. A method for treating hypoglycemia, comprising administering an effective amount of a compound or pharmaceutically acceptable salt according to claim 1 to a subject in need thereof.
11. A method for treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance, or obesity, comprising administering an effective amount of a compound or pharmaceutically acceptable salt according to claim 1 to a subject in need thereof.
12. A pharmaceutical composition, which comprises a fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 1 and a pharmaceutically acceptable carrier.
13. A method for increasing the sugar-transporting capacity, comprising administering an effective amount of a compound or pharmaceutically acceptable salt according to claim 3 to a subject in need thereof.
14. A method for treating hypoglycemia, comprising administering an effective amount of a compound or pharmaceutically acceptable salt according to claim 3 to a subject in need thereof.
15. A method for treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance, or obesity, comprising administering an effective amount of a compound or pharmaceutically acceptable salt according to claim 3 to a subject in need thereof.
16. A pharmaceutical composition, which comprises a fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 3 and a pharmaceutically acceptable carrier.
17. A method for increasing the sugar-transporting capacity, comprising administering an effective amount of a compound or pharmaceutically acceptable salt according to claim 4 to a subject in need thereof.
18. A method for treating hypoglycemia, comprising administering an effective amount of a compound or pharmaceutically acceptable salt according to claim 4 to a subject in need thereof.
19. A method for treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance, or obesity, comprising administering an effective amount of a compound or pharmaceutically acceptable salt according to claim 4 to a subject in need thereof.
20. A pharmaceutical composition, which comprises a fused polycyclic compound or pharmaceutically acceptable salt thereof according to claim 4 and a pharmaceutically acceptable carrier.