Compositions against cancer antigen LIV-1 and uses thereof
Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
1. A method of treating breast cancer, comprising administering an effective dose of an antibody that specifically binds to LIV-1 polypeptide to a patient diagnosed as having LIV-1 + breast cancer, wherein the antibody is conjugated to a therapeutic moiety, and wherein the LIV-1 polypeptide comprises the amino acid sequence shown in SEQ ID NO:19.
2. The method of claim 1 , wherein the antibody is a monoclonal antibody.
3. The method of claim 1 , wherein the antibody is an antibody fragment.
4. The method of claim 1 , wherein the antibody is a humanized antibody.
5. The method of claim 1 , wherein the therapeutic moiety is a cytotoxic agent.
6. The method of claim 1 comprising administering the antibody with a pharmaceutically acceptable excipient.