Antimicrobial bandage material comprising superabsorbent and non-superabsorbent layers
View Patent ↗This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.
1. An antimicrobial bandage material comprising;
a. a first substrate;
b. an antimicrobial superabsorbent polymer, wherein said superabsorbent polymer is non-leachably bound to said first substrate, and wherein said superabsorbent polymer imparts antimicrobial activity to the bound said first substrate;
c. a second substrate;
d. a non-superabsorbent polymer, wherein said non-superabsorbent polymer is non-leachably bound to said second substrate, and wherein said non-superabsorbent polymer imparts antimicrobial activity to the bound said second substrate;
wherein said second substrate and bound non-superabsorbent polymer covers or surrounds said first substrate and bound superabsorbent polymer,
wherein said superabsorbent polymer consists essentially of polymers of a first monomeric quaternary ammonium salt and at least one cross linking agent,
wherein said non-superabsorbent polymer consists essentially of polymers of a second monomeric quaternary ammonium salt, and
wherein said first monomeric quaternary ammonium salt and second monomeric quaternary ammonium salt are selected, independently, from the group consisting of [2-(methacryloxloxy)ethyl]trimethylammonium chloride, also known as TMMC, [2-(acryloyloxy)ethyl]trimethylammonium methyl sulfate, also known as TMAS, [2-(acryloyloxy)ethyl)trimethylammonium chloride, also known as TMAC, [3-(methacryloylamino) propyl]trimethylammonium chloride, also known as TMAPMC, vinylbenzyltrimethylammonium chloride, also known as VBTAC, and diallyldialkylammonium salts.
2. The antimicrobial bandage material of claim 1 , wherein said cross linking agent is an acrylate cross linking agent.
3. The antimicrobial bandage material of claim 1 , wherein said cross linking agent is poly(ethylene glycol)diacrylate.
4. The antimicrobial bandage material of claim 1 , wherein said first monomeric quaternary ammonium salt is selected from the group consisting of VBTAC and diallyldialkylammonium salts.
5. The antimicrobial bandage material of claim 4 , wherein said first monomeric quaternary ammonium salt is a diallyldialkylammonium salt.
6. The antimicrobial bandage material of claim 5 , wherein said first monomeric quaternary ammonium salt is diallyldimethylammonium chloride, also known as DADMAC.
7. The antimicrobial bandage material of claim 1 , wherein said second monomeric quaternary ammonium salt is selected from the group consisting of VBTAC and diallyldialkylammonium salts.
8. The antimicrobial bandage material of claim 7 , wherein said second monomeric quaternary ammonium salt is a diallyldialkylammonium salt.
9. The antimicrobial bandage material of claim 8 , wherein said second monomeric quaternary ammonium salt is diallyldimethylammonium chloride, also known as DADMAC.
10. The antimicrobial bandage material of claim 1 , wherein either or both of said first substrate and said second substrate are comprised, in whole or in part, of cellulose, or other naturally-derived polymers.
11. The antimicrobial bandage material of claim 1 , wherein either or both of said first substrate and said second substrate are comprised, in whole or in part, of a synthetic polymer.
12. The antimicrobial bandage material of claim 11 , wherein said synthetic polymer is polyethylene, polypropylene, nylon, polyester, polyurethane, or silicone.
13. The antimicrobial bandage material of claim 1 , wherein said antimicrobial bandage material comprises all or part of a wound dressing , an intrinsically antimicrobial absorbent dressing, a burn dressing, or a gauze roll.
14. The antimicrobial bandage material of claim 1 , wherein either or both of said first substrate and said second substrate is a woven or nonwoven flexible matrix, and wherein said antimicrobial bandage material is formed into the shape of a wound dressing , an intrinsically antimicrobial absorbent dressing, a burn dressing, or a gauze roll.
15. The antimicrobial bandage material of claim 5 , wherein either or both of said first substrate and said second substrate is a woven or nonwoven flexible matrix, and wherein said antimicrobial bandage material is formed into the shape of a wound dressing , an intrinsically antimicrobial absorbent dressing, a burn dressing, or a gauze roll.
16. The antimicrobial bandage material of claim 6 , wherein either or both of said first substrate and said second substrate is a woven or nonwoven flexible matrix, and wherein said antimicrobial bandage material is formed into the shape of a wound dressing , an intrinsically antimicrobial absorbent dressing, a burn dressing, or a gauze roll.
17. The antimicrobial bandage material of claim 8 , wherein either or both of said first substrate and said second substrate is a woven or nonwoven flexible matrix, and wherein said antimicrobial bandage material is formed into the shape of a wound dressing , an intrinsically antimicrobial absorbent dressing, a burn dressing, or a gauze roll.
18. The antimicrobial bandage material of claim 9 , wherein either or both of said first substrate and said second substrate is a woven or nonwoven flexible matrix, and wherein said antimicrobial bandage material is formed into the shape of a wound dressing , an intrinsically antimicrobial absorbent dressing, a burn dressing, or a gauze roll.
19. The antimicrobial bandage material of claim 1 , further comprising a hemostatic agent.
20. The antimicrobial bandage material of claim 1 , further comprising an indicator.