IP Library › Granted Patent US 8,367,691
Granted Patent B2
US 8,367,691 · App. 12/794,202 · Granted Feb 5, 2013

Modulators of muscarinic receptors

Inventors: Lewis R. Makings (Encinitas, CA); Miguel Garcia-Guzman Blanco (San Diego, CA); Dennis J. Hurley (San Marcos, CA); Ioana Drutu (La Jolla, CA); Gabriel Raffai (Tucson, AZ); Daniele M. Bergeron (La Mesa, CA); Akiko Nakatani (San Diego, CA); Andreas P. Termin (Encinitas, CA); Alina Silina (San Diego, CA)
Assignee: Vertex Pharmaceutical Incorporated
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Quick Facts
Patent No.
US 8,367,691
App. No.
12/794,202
Granted
Feb 5, 2013
Kind
B2
Abstract

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Claims (5)

1. A compound selected from:

2. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutical carrier.

3. A method of modulating activity of a muscarinic receptor, comprising the step of contacting said receptor with a compound selected from:

4. The method of claim 3 , wherein the compound selectively modulates the M 1 or M 4 muscarinic receptor.

5. A method of treating or reducing the severity of a disease or condition in a patient, wherein said disease or condition is selected from Attention Deficit Hyperactivity Disorder (ADHD), schizophrenia, pain, Parkinson's disease, and Glaucoma, wherein said method comprises the step of contacting said patient with a compound as described in claim 3 .

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Oct 14, 2016
From: MACQUARIE US TRADING LLC
To: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 040357/0001 →
SECURITY INTEREST Recorded Jul 10, 2014
From: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
To: MACQUARIE US TRADING LLC
Reel/Frame 033292/0311 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2012
From: MAKINGS, LEWIS R.; BLANCO, MIGUEL GARCIA-GUZMAN; HURLEY, DENNIS J.; DRUTU, IOANA; RAFFAI, GABRIEL; BERGERON, DANIELE M.; NAKATANI, AKIKO; TERMIN, ANDREAS P.; SILINA, ALINA
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 028037/0317 →
Continuity (4)
Division 11359960 · Feb 22, 2006
Continuation In Part 11208386 · Aug 19, 2005
Provisional Application 60602731 · Aug 19, 2004
Related Publication 20100311746A1 · Dec 9, 2010