Phospholipid compositions and uses thereof
We have discovered that phospholipids diundecanoyl (C11:0-C11:0) and dilauroyl (C12:0-C12:0) phosphatidylcholine (PC) act as agonists of the LRH-1 receptor. We have also shown that administration of these lipids to diabetic mice reduces blood glucose levels. On the basis of these discoveries, the present invention features compositions that include these lipids and structurally related lipids. Also featured are methods of treating metabolic disorders and inflammatory bowel disease, lowering blood glucose levels, and increasing LRH-1 receptor activity in a subject by administration of these lipids.
1. A method of treating a subject having type II diabetes, said method comprising administering to said subject an effective amount of at least one phosphatidylcholine (PC) lipid having 22-24 total carbon atoms in its fatty acid tails, wherein each fatty acid tail is 10, 11, 12, or 13 carbon atoms in length.
2. The method of claim 1 , wherein said subject is a human.
3. The method of claim 1 , wherein said composition comprises DUPC.
4. The method of claim 1 , wherein said composition comprises DLPC.
5. The method of claim 1 , wherein said composition is administered orally.
6. The method of claim 1 , wherein the said lipid is present in an enriched lipid composition.