MECS dialyzer method
The present invention provides methods and apparatus for cleansing blood through hemodialysis by the process of diffusion across a membrane into dialysate. This dialyzer also removes solutes from the blood by a process of convection, where fluid and dissolved solutes pass through the membrane out of the blood. In one embodiment in accordance with the present invention, the MECS dialyzer uses a counter-flow between the dialysate and blood through a plurality of microchannels. The dialyzer comprises a plurality of flat semi-permeable membranes interleaved between microchannel sheets to define a plurality of flow channels. The stack of membranes and microchannel sheets are aligned and consolidated to form the MECS dialyzer. The MECS dialyzer acts as a flow manifold with ports and headers to collect the blood and dialysate and direct them to and from the microchannels.
1. A method for dialysis of blood, comprising:
providing a dialyzer comprising:
a plurality of semipermeable membrane sheets; and
a plurality of flow separators, the semipermeable membrane sheets and flow separators arranged in alternating configuration and coupled into a laminae stack defining a plurality of parallel microchannels layers, each microchannel layer comprising a plurality of first microchannels and a plurality of second microchannels, each first microchannel and each second microchannel being defined by two of the plurality of semipermeable membrane sheets, the first microchannels and the second microchannels of each microchannel layer being in fluid communication with each other via one of the plurality of semipermeable membrane sheets therebetween, the blood-handling apparatus in fluid communication with the first microchannels, the dialysate-handling apparatus in fluid communication with the second microchannels;
supplying the first microchannels with blood at a first end of the first microchannels;
supplying the second microchannels with dialysate at a second end of the second microchannels;
withdrawing blood from the first microchannels at a second end of the first microchannels; and
withdrawing dialysate from the second microchannels at a first end of the second microchannels.
2. The method of claim 1 , wherein the flow of blood through the set of first microchannels is non-turbulent.
3. The method of claim 1 wherein the flow of blood through the set of first microchannels is laminar.
4. The method of claim 1 wherein the first and second microchannels have an internal dimension of up to 1000 microns.
5. The method of claim 1 wherein each of the semipermeable membrane sheets have a sheet first side and a sheet second side opposite the sheet first side and a sheet first end and a sheet second end opposite the sheet first end; and wherein each flow separator being an elongated member, at least two flow separators depend from each of the sheet first side and sheet second side of each of the plurality of semipermeable membrane sheets, the at least two flow separators being spaced a predetermined distance apart and substantially parallel therewith, a sheet first side of one of the semipermeable membrane sheets being adjacent a sheet second side of another one of the semipermeable membrane sheets such that respective flow separators of adjacent semipermeable membrane sheets are in facing relationship and coupled together therefore defining coupled flow separators, wherein the plurality of semipermeable membrane sheets and coupled flow separators define alternating first microchannel layers comprising substantially parallel first microchannels and second microchannel layers comprising substantially parallel second microchannels the first microchannels and second microchannels extending from each of the sheet first end to the sheet second end, the first microchannels and second microchannels being in fluid communication with each other via one of the plurality of semipermeable membrane sheets therebetween, the first microchannels operable for receiving a first fluid stream comprising blood and the second microchannels operable for receiving a second fluid stream comprising dialysate; the dialyzer further comprising a first header and a second header, the first header comprising an inlet in fluid communication with the first microchannels at the sheet first end and an outlet in fluid communication with the second microchannels at the sheet first end, the second header comprising an inlet in fluid communication with the second microchannels at the sheet second end and an outlet in fluid communication with the first microchannels at the sheet second end.
6. The method of claim 5 , wherein the first microchannels of each first microchannel layer are parallel therewith and the second microchannels of each second microchannel layer are parallel therewith.
7. A method for dialysis of blood, comprising:
providing a dialyzer comprising:
a plurality of semipermeable membrane sheets, each of the semipermeable membrane sheets having a sheet first side and a sheet second side opposite the sheet first side and a sheet first end and a sheet second end opposite the sheet first end; and
a plurality of flow separators, each flow separator being an elongated member, at least two flow separators depend from each of the sheet first side and sheet second side of each of the plurality of semipermeable membrane sheets, the at least two flow separators being spaced a predetermined distance apart and substantially parallel therewith, a sheet first side of one of the semipermeable membrane sheets being adjacent a sheet second side of another one of the semipermeable membrane sheets such that respective flow separators of adjacent semipermeable membrane sheets are in facing relationship and coupled together therefore defining coupled flow separators, wherein the plurality of semipermeable membrane sheets and coupled flow separators define alternating first microchannel layers comprising substantially parallel first microchannels and second microchannel layers comprising substantially parallel second microchannels, each first microchannel and each second microchannel being defined by two of the plurality of semipermeable membrane sheets, the first microchannels and second microchannels extending from each of the sheet first end to the sheet second end, the first microchannels and second microchannels being in fluid communication with each other via one of the plurality of semipermeable membrane sheets therebetween, the first microchannels operable for receiving a first fluid stream comprising blood and the second microchannels operable for receiving a second fluid stream comprising dialysate;
supplying the first microchannels with blood at an end of the first microchannels;
withdrawing blood from the first microchannels at an other end of the first microchannels;
supplying the second microchannels with dialysate at an end of the second microchannels; and
withdrawing dialysate from the second microchannels at an other end of the second microchannels.
8. The method of claim 7 , wherein the first microchannels and second microchannels are parallel therewith.
9. The dialyzer of claim 7 , wherein the first microchannels and second microchannels are orthogonal therewith.
10. The method of claim 7 wherein the flow of blood through the set of first microchannels is countercurrent to the flow of dialysate through the set of second microchannels.
11. The method of claim 7 wherein the flow of blood through the set of first microchannels is concurrent to the flow of dialysate through the set of second microchannels.
12. The method of claim 7 wherein the flow of blood through the set of first microchannels is crosscurrent to the flow of dialysate through the set of second microchannels.
13. A method for dialysis of blood, comprising:
providing a dialyzer comprising a plurality of first microchannels and a plurality of second microchannels, each first microchannel and each second microchannel being defined by two semipermeable membrane sheets and two flow separators, each of the first microchannels and second microchannels being parallel to each other, and in fluid communication with each other via at least one of the two semipermeable membrane sheets, the first microchannels being operable for receiving a first fluid stream comprising blood and the second microchannels operable for receiving a second fluid stream comprising dialysate;
supplying the first microchannels with blood at an end of the first microchannels;
withdrawing blood from the first microchannels at an other end of the first microchannels;
supplying the second microchannels with dialysate at an end of the second microchannels; and
withdrawing dialysate from the second microchannels at an other end of the second microchannels.
14. The method of claim 13 , wherein the first microchannels and second microchannels are parallel therewith.
15. The dialyzer of claim 13 , wherein the first microchannels and second microchannels are orthogonal therewith.
16. The method of claim 13 wherein the flow of blood through the set of first microchannels is countercurrent to the flow of dialysate through the set of second microchannels.
17. The method of claim 13 wherein the flow of blood through the set of first microchannels is concurrent to the flow of dialysate through the set of second microchannels.
18. The method of claim 13 wherein the flow of blood through the set of first microchannels is crosscurrent to the flow of dialysate through the set of second microchannels.