Compositions and methods for treating cancer by inhibiting the secretion of microparticles
Novel peptides that inhibit the release of microparticles from cells are disclosed. Also disclosed are polynucleotides encoding the peptides, expression vectors carrying the polynucleotides and methods for treating tumors using the novel peptides.
1. A method for treating a tumor, comprising:
administering to a subject in need of such treatment an effective amount of a polynucleotide encoding a peptide comprising SEQ ID NO: 2, wherein said polynucleotide is capable of expressing said peptide in vivo.
2. The method of claim 1 , wherein said peptide comprises the amino acid sequence of SEQ ID NO: 3.
3. The method of claim 1 , wherein said peptide comprises at least one SEQ ID NO: 1 motif at the N-terminal.
4. The method of claim 1 , wherein said peptide comprises at least one SEQ ID NO: 1 motif at the C-terminal.
5. A method for treating a tumor, comprising:
administering to a subject in need of such treatment an effective amount of an expression vector comprising a polynucleotide encoding a peptide comprising SEQ ID NO: 2, wherein said expression vector is capable of expressing said peptide in vivo.
6. The method of claim 5 , wherein said peptide comprises the amino acid sequence of SEQ ID NO: 3.
7. The method of claim 5 , wherein said peptide comprises at least one SEQ ID NO: 1 motif at the N-terminal.
8. The method of claim 5 , wherein said peptide comprises at least one SEQ ID NO: 1 motif at the C-terminal.
9. The method of claim 5 , wherein said expression vector is a viral vector.
10. The method of claim 5 , wherein said expression vector is a non-viral vector.