Medical implant containing an antioxidative substance
One embodiment of the invention concerns a medical implant having a basic body that includes the antioxidative substance squalene incorporated into at least one of the basic body and a coating on at least a portion of the basic body, the incorporated squalene being present in quantities of 0.4 μg to 2000 μg.
1. An implant having a basic body and comprising squalene, wherein the squalene is polymerized with at least one polymer in at least one of the basic body and a polymeric coating, and the squalene is present in quantities of 0.4 μg to 2000 μg.
2. An implant according to claim 1 , characterized by, that the squalene is present in quantities of 4 μg to 400 μg.
3. An implant according to claim 1 , characterized by, that the squalene is present in quantities of 40 μg to 100 μg.
4. An implant according to claim 1 , characterized by, that the implant is a vascular implant.
5. An implant according to claim 4 , characterized by, that the implant is provided with one of a biocorrodible or permanent basic body.
6. An implant according to claim 5 , characterized by, that the biocorrodible basic body comprises a biocorrodible metallic active substance comprising alloys of the group of magnesium, iron, zinc, manganese or wolfram.
7. An implant according to claim 1 , characterized by, that in addition, the implant further comprises at least one pharmaceutically active substance.
8. An implant according to claim 1 , wherein the basic body is biocorrodible and consists of an alloy of the group of magnesium, iron, zinc, manganese or wolfram.
9. An implant according to claim 1 wherein:
the squalene is polymerized with at least one polymer in the polymeric coating deposited on at least a portion of the basic body that has a thickness of between about 1 μm and about 100 μm;
the polymerized sqaulene is present in an amount of between about 40 to about 100 μg; and,
the basic body comprises a magnesium alloy.
10. An implant according to claim 1 wherein:
the squalene is polymerized with at least one polymer in the polymeric coating and wherein the squalene is present in a concentration of between about 1% to 2% (wt) in a the polymeric coating deposited on at least a portion of the basic body having a thickness of between about 3 μm and about 15 μm; and
the basic body comprises an alloy that includes yttrium and at least about 70% (wt) magnesium.
11. The implant of claim 1 , wherein the polymeric coating comprises poly-L-lactic acid (PLLA) and wherein the squalene is cross-linked with PLLA.
12. The implant of claim 1 , wherein the squalene is cross-linked.
13. The implant of claim 1 , wherein the squalene is incorporated into the basic body.
14. The implant of claim 13 , wherein the basic body is biostable wherein it does not dissolve in a physiologic environment and the squalene is not released into the physiologic environment.
15. A medical implant comprising:
a biocorrodible basic body;
a biodegradable polymeric coating covering at least a portion of the basic body, including squalene, wherein the squalene is polymerized with at least one polymer in the coating in an amount of between about 0.4 μg to 2000 μg; and
a pharmaceutically active material in a concentration of between about 0.2 to 3.5μg/mm 2 , the coating having a thickness of between about 3 μm and about 15 μm.
16. An implant according to claim 15 wherein the implant is a vascular implant, and wherein the basic body is made of an alloy that includes yttrium, a rare earth metal, and at least about 50% (wt) magnesium.