Eyelid margin wipes comprising chemical means for temperature adjustment

1. An eyelid margin wipe for treatment of disorders of an eyelid or eyelid margin comprising: at least two components adapted to change a temperature of the wipe from an ambient temperature upon reaction with each other to an elevated temperature range of from about 40° C. to about 55° C.; a water-impermeable container that prevents the at least two components from coming into contact with a closed eye when in use; a seal for keeping the at least two components separate until temperature change is initiated, wherein the elevated temperature range is reached within 2 minutes after the temperature change is initiated and is maintained for at least 5 minutes without causing damage to a delicate eye region; and at least one agent selected from the group consisting of cleansing agents and surfactant agents, wherein the wipe has a size of one human eye region.

2. The eyelid margin wipe according to claim 1 , wherein the disorder of the eyelid margin is meibomian gland dysfunction.

3. The eyelid margin wipe according to claim 1 , wherein the wipe is sterile.

4. The eyelid margin wipe according to claim 1 , wherein the reaction is an exothermic reaction.

5. The eyelid margin wipe according to claim 1 , wherein the at least two components comprise MgSO 4 and water.

6. The eyelid margin wipe according to claim 1 , wherein the at least two components comprise an inorganic salt and water.

7. The eyelid margin wipe according to claim 1 , wherein the at least two components comprise an oxidising agent and a reducing agent.

8. The eyelid margin wipe according to claim 1 , wherein the temperature is changed to a temperature of from about 40° C. to about 45° C.

9. The eyelid margin wipe according to claim 1 , wherein the temperature is changed to a temperature of from about 45° C. to about 52° C.

10. The eyelid margin wipe according to claim 1 , wherein the elevated temperature is reached within 1 minute.

11. The eyelid margin wipe according to claim 1 , wherein the temperature is maintained at the elevated temperature range for more than 5 minutes.

12. The eyelid margin wipe according to claim 1 , wherein the temperature is maintained at the elevated temperature range for 10 minutes or more.

13. The eyelid margin wipe according to claim 1 , wherein the wipe is square, rectangular, circular or ovoid shaped.

14. The eyelid margin wipe according to claim 1 , wherein the wipe is eye-shaped.

15. The eyelid margin wipe according to claim 1 , wherein the wipe is curved to correspond to a contour of an eye.

16. The eyelid margin wipe according to claim 1 , wherein the wipe is coated with a polymeric material capable of moulding to a surface of the eye.

17. The eyelid margin wipe according to claim 1 , wherein the wipe is coated with a polymeric material which softens at a temperature above ambient temperature, such that, in use, the polymeric material is capable of moulding to the surface of the eye.

18. The eyelid margin wipe according to claim 1 , further comprising at least one active agent.

19. The eyelid margin wipe according to claim 1 , further comprising a drug delivery system.

20. The eyelid margin wipe according to claim 1 , further comprising at least one additional agent selected from the group consisting of antistatic agents, preservatives, antioxidants, antimicrobial agents, chelating agents, emollients, emulsifying agents, buffering/neutralising agents, humectants, thickeners, viscosity controlling agents, antistatic agents, and conditioning agents.

21. The eyelid margin wipe according to claim 20 , wherein the at least one additional agent is incorporated in a thermo-responsive polymer layer coated on a surface of the wipe.

22. The eyelid margin wipe according to claim 20 , wherein the viscosity controlling agent is polyethylene glycol (PEG).

23. The eyelid margin wipe according to claim 20 , further comprising a reflective layer and/or a conductive layer to direct heat towards one surface of the wipe.

24. The eyelid margin wipe according to claim 1 , wherein the at least one agent is comprising a cleansing agent.

25. The eyelid margin wipe according to claim 1 , wherein the at least one agent is a surfactant agent.

26. The eyelid margin wipe according to claim 1 , wherein at least one of the cleansing agent and the surfactant agent is selected from the group consisting of PEG-80 sorbitan laurate, sodium trideceth sulfate, PEG-150 distearate, cocamidopropyl hydroxysultaine, sodium laureth-13 carboxylate, disodium lauroamphodiacetate, polysorbate 80, polysorbate 20, poloxamer 184, ammonium laureth sulfate, ceteareth 20, ceteareth 25, cocamidopropyl betaine, disodium laureth sulfosuccinate, disodium lauriminodipropionate, disodium lauroamphodipropionate, glycol stearate, hydrogenated castor oil, laureth-23, magnesium laureth, oleth sulfate, PEG-20 stearate, PEG-35 castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-7 hydrogenated castor oil, PEG-75 lanolin, poloxamer, sodium laureth sulfate, sodium trideceth sulfate, sodium C12-15 pareth 15 sulfonate, and sodium C14-16 olefin sulfonate.

27. The eyelid margin wipe according to claim 1 , further comprising an indicator which confirms to a user that a required temperature has been reached.

28. The eyelid margin wipe according to claim 27 , wherein the indicator is a temperature sensitive color indicator configured to change from a first color to a second color when the required temperature has been reached.

29. The eyelid margin wipe according to claim 28 , wherein the indicator is configured to undergo a reversible color change, such that when the wipe is no longer at the required temperature or has fallen outside of a required temperature range, the indicator is configured to revert to the first color.

30. The eyelid margin wipe according to claim 28 , wherein at least a part of the wipe is coated with an indicator selected from the group consisting of a temperature reactive ink and a temperature reactive dye.

31. The eyelid margin wipe according to claim 1 , wherein the seal is a frangible seal.