Method and apparatus for determining vascular health conditions
The present invention relates to assessing and measuring vascular and endothelial function. A vasostimulant is provided to a patient to stimulate hemodynamic activity in a selected extremity and vascular function is assessed by monitoring a change in a blood flow, skin temperature and/or blood oxygen content at the selected extremity and assessing the patient's vascular function based upon the monitoring.
1. A method for assessing arterial reactivity in a patient, comprising:
a) providing a vasodilating stimulant to a patient by creating an arterial occlusion at a body part of said patient using one or more pressure cuffs thereby stimulating arterial reactivity in a first region of said body part of said patient;
b) simultaneously monitoring a patient's skin surface temperature at the first region and at a second control region before the arterial occlusion, during the arterial occlusion, and after the arterial occlusion is removed and until an equilibrium temperature is achieved using a temperature measurement device that does not substantially apply any one of thermal energy, positive pressure and negative pressure to the skin surface; wherein said second control region and said first region are located at contralateral body parts; and
c) identifying a baseline temperature at the first region before the arterial occlusion;
d) identifying a peak temperature at the first region after the arterial occlusion; and
e) assessing arterial reactivity in said patient based on temperature changes at the second control region and a rebound temperature change related to said baseline temperature and said peak temperature at the first region.
2. The method of claim 1 for assessing arterial reactivity further comprising:
a) creating the arterial occlusion for a predetermined period of time; and
b) ceasing the occlusion after the predetermined period of time.
3. The method of claim 1 , wherein providing a vasodilating stimulant comprises occluding blood flow to at least one of: (i) a leg, (ii) ankle, (iii) toe, (iv) arm, (v) wrist, and (vi) a finger.
4. The method of claim 1 , wherein said monitoring occurs from a time prior to the beginning of said compression until a time after the hemodynamic activity has reached equilibrium.
5. The method of claim 1 , wherein the monitoring comprises measuring changes in temperature at one of the patient's fingertips.
6. The method of claim 5 , further comprising plotting the measured changes in temperature as a function of time.
7. A method for assessing arterial reactivity in a patient comprising:
a) measuring a first equilibrium skin temperature at a first region of a body part of said patient using a temperature measurement device that does not substantially apply any one of thermal energy, positive pressure, and negative pressure to said first region of the patient;
b) compressing arteries of said body part of the patient using a pressure cuff such that arterial blood flow in said first region of said body part is occluded;
c) simultaneously measuring skin temperature at the first region and at a second control region of said body part during cuff compression, after release of the cuff and until a second temperature equilibrium is achieved; wherein the second control region does not undergo arterial blood flow occlusion said cuff compression;
d) identifying a peak temperature at the first region after release of the cuff; and
e) assessing the patient's arterial reactivity based upon temperature changes at the second control region and a rebound temperature change related to said first equilibrium temperature and said peak temperature at the first region.
8. The method of claim 7 , wherein said first region is a digit.
9. The method of claim 8 , wherein the digit is a finger and the temperature is measured on a fingertip.
10. The method of claim 7 , comprising occluding blood flow in at least one extremity for a predetermined period of time and ceasing compression after the predetermined period of time, wherein said first region consists of one or more of: a leg, ankle, toe, arm, wrist, and a finger.
11. The method of claim 7 , wherein the measuring is conducted from a time prior to the occluding blood flow with a compressing cuff until a time after a equilibrium temperature is reached after ceasing compression.
12. The method of claim 7 , further comprising plotting the measured temperature as a function of time.
13. A method for determining a arterial reactivity status in a patient comprising:
a) initiating monitoring of skin surface temperature at a selected point of a selected region the patient until a first equilibrium temperature is reached using a temperature sensor that does not substantially change the skin temperature;
b) while continuing the monitoring, occluding arterial blood flow to the selected point for a predetermined period of time by providing a vasodilating stimulant using a pressure cuff and ceasing the occlusion after the predetermined period of time;
c) simultaneously with said monitoring and said occluding, monitoring skin surface temperature at a control point that does not undergo arterial flow occlusion until the skin surface temperature of the selected point has reached a second equilibrium after ceasing the occlusion;
d) identifying a peak temperature at the selected point after release of the cuff; and
e) assessing the patient's arterial reactivity based upon temperature changes at the control point and a rebound temperature change related to said first equilibrium temperature and said peak temperature at the selected point.
14. The method of claim 13 , further comprising plotting the monitored temperature as a function of time.
15. The method of claim 13 , wherein the selected region is a finger and the temperature is measured at a point on the skin surface of a fingertip.
16. The method of claim 13 , wherein the blood flow is occluded at one or more regions selected from the group consisting of: a leg, ankle, toe, arm, wrist, and a finger.