Compositions and methods for administering compartmentalized frozen particles
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
1. A frozen particle composition, comprising:
a frozen citrate solution particle defining at least one cavity containing at least one liposome;
the at least one liposome containing at least one agent of cyanoacrylate, isocyanate, chitin, polyacrylic acid, poly (L-lactic acid), polyglycolide, polylactic acid, polyether, polyol, polyvinylpyrrolidone, pyroxylin, polymethacrylate-isobutene-monoisopropylmaleate, polylactic-co-glycolic-acid, carboxymethylcellulose, or methacrylate; and
wherein the frozen citrate solution particle is a frozen solution of sodium citrate in water, and wherein the frozen citrate solution particle is coated in one or more of collagen, fibrin, Factor XIII, Factor XII, thrombin, fibrinogen, hyaluronate, or glycosaminoglycan; and is approximately one micrometer or less, approximately one nanometer or less, or any size value therebetween.
2. The frozen particle composition of claim 1 , wherein at least one cavity is configured to physically or chemically separate the at least one agent from at least one other cavity of the frozen particle.
3. The frozen particle composition of claim 1 , wherein at least one cavity is configured to physically or chemically separate from at least one other cavity of the frozen particle during administration.
4. The frozen particle composition of claim 1 , wherein the at least one cavity is an inner core cavity of at least one frozen particle.
5. The frozen particle composition of claim 1 , wherein the at least one cavity includes an inner core cavity and wherein the at least one agent is at least one of a liquid or gas.
6. The frozen particle composition of claim 1 , wherein the at least one cavity has a higher concentration of the at least one agent than any other cavity.
7. The frozen particle composition of claim 6 , wherein the at least one cavity includes a graduated concentration of the at least one agent.
8. The frozen particle composition of claim 1 , wherein the at least one cavity includes varying levels of the at least one agent.
9. The frozen particle composition of claim 1 , wherein the at least one agent is fractionated.
10. The frozen particle composition of claim 1 , wherein the at least one cavity includes one or more layers of at least one agent.
11. The frozen particle composition of claim 1 , further including two or more cavities, each containing at least one different agent.
12. The frozen particle composition of claim 1 , wherein the at least one agent includes one or more of a pro-drug or precursor compound.
13. The frozen particle composition of claim 1 , wherein the at least one agent includes one or more time-release or extended-release formulations.
14. The frozen particle composition of claim 1 , wherein the at least one agent includes an activatable agent.
15. The frozen particle composition of claim 1 , further a plurality of frozen particles that are approximately uniform in size, shape, weight, or density.
16. The frozen particle composition of claim 1 , further including at least one pharmaceutically-acceptable carrier or excipient.
17. The frozen particle composition of claim 1 , further including at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.
18. The frozen particle composition of claim 17 , wherein the detection material is intermixed with the at least one frozen particle composition.
19. The frozen particle composition of claim 17 , wherein the detection material is located in the at least one frozen particle composition.
20. The frozen particle composition of claim 17 , wherein the detection material is located in at least one cavity of at least one frozen particle composition.
21. The frozen particle composition of claim 17 , wherein the detection material includes at least one electronic identification device.
22. The frozen particle composition of claim 21 , wherein the at least one electronic identification device includes at least one radio frequency identification device.
23. The frozen particle composition of claim 17 , wherein the detection material includes at least one radioactive element.
24. The frozen particle composition of claim 17 , wherein the at least one radioactive element includes one or more of 32 P, 35 S, 13 C, 131 I, 191 Ir, 192 Ir, 193 Ir, or 3 H.
25. The frozen particle composition of claim 17 , wherein the detection material includes at least one luminescent, colorimetric or odorous substance.
26. The frozen particle composition of claim 25 , wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.
27. The frozen particle composition of claim 17 , wherein the at least one detection material includes one or more of a dye, pigment, luminescent substance, fluorescent substance, or phosphorescent substance.
28. The frozen particle composition of claim 17 , wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.
29. The frozen particle composition of claim 1 , wherein the at least one agent includes at least one nontoxic, biocompatible, bioresorbable, or biodegradable agent.