IP Library › Granted Patent US 8,552,165
Granted Patent B2
US 8,552,165 · App. 12/632,911 · Granted Oct 8, 2013

Immunostimulatory oligonucleotides

Inventors: Heather Davis (Donrobin, CA); Risini Weeratna (Ottawa, CA)
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Quick Facts
Patent No.
US 8,552,165
App. No.
12/632,911
Granted
Oct 8, 2013
Kind
B2
Abstract

The invention relates to immunostimulatory oligonucleotides and methods of using immunostimulatory oligonucleotides to induce an antigen-specific immune response. The invention further relates to a vaccine that comprises an immunostimulatory oligonucleotide and an antigen, and comprises a pharmaceutically acceptable carrier. The immunostimulatory oligonucleotides of the invention, in some embodiments, include one or more modified linkage(s).

Claims (6)

1. An immunostimulatory oligonucleotide comprising the nucleotide sequence

5′ TCGTCGTTTTTCGGTGCTTTT 3′.

(SEQ ID NO: 1)

2. The immunostimulatory oligonucleotide of claim 1 , wherein the oligonucleotide comprises one or more modified linkages.

3. The immunostimulatory oligonucleotide of claim 2 , wherein the oligonucleotide comprises one or more phosphorothioate linkages.

4. The immunostimulatory oligonucleotide of claim 1 , wherein the oligonucleotide comprises at least one lipophilic substituted nucleotide analog and a pyrimidine-purine dinucleotide.

Assignments (1)
ASSIGNEE ADDRESS CORRECTION Recorded Mar 15, 2023
From: COLEY PHARMACEUTICAL GROUP, INC.
To: COLEY PHARMACEUTICAL GROUP, INC.
Reel/Frame 063100/0388 →
Continuity (3)
Provisional Application 61121022 · Dec 9, 2008
Provisional Application 61181799 · May 28, 2009
Related Publication 20100143400A1 · Jun 10, 2010