Lumen-traveling biological interface device and method of use
Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry.
1. A method of emplacing a neural stimulation device, comprising:
causing an untethered self-propelling neural stimulation device to travel within a body tube tree of a subject toward a target site;
detecting with a sensor on the untethered self-propelling neural stimulation device a branch point including two or more branches within the body tube tree;
selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, an index of refraction, a pressure, a temperature, a blood flow, a direction of blood flow, a viscosity, a shear, a pH, a presence or absence of a chemical, or a man-made structure;
upon detecting the branch point, causing the untethered self-propelling neural stimulation device to enter the branch leading toward the target site;
causing the untethered self-propelling neural stimulation device to stop traveling upon reaching the target site; and
delivering a neural stimulus at the target site.
2. The method of claim 1 , including introducing the untethered self-propelling neural stimulation device into the body tube tree of a subject.
3. The method of claim 1 , including causing the untethered self-propelling neural stimulation device to engage a wall of the body tube tree at the target site.
4. The method of claim 1 , wherein the body tube tree is a vascular system of the subject.
5. The method of claim 1 , wherein the body tube tree is a respiratory tract of the subject.
6. The method of claim 1 , wherein the body tube tree is a CSF-space of the subject.
7. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to travel within the body tube tree of the subject toward the target site includes causing the untethered self-propelling neural stimulation device to travel within the body tube tree under the control of a control system located at least in part on the untethered self-propelling neural stimulation device.
8. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to travel within the body tube tree of the subject toward the target site includes causing the untethered self-propelling neural stimulation device to travel within the body tube tree toward a target site located within a chamber of a heart of the subject.
9. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to travel within the body tube tree of the subject toward the target site includes causing the untethered self-propelling neural stimulation device to travel within the body tube tree toward a target site located within a brain of the subject.
10. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to travel within the body tube tree of the subject toward the target site includes causing the untethered self-propelling neural stimulation device to travel within the body tube tree toward a target site located within a spinal canal of the subject.
11. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to travel within the body tube tree of the subject toward the target site includes causing the untethered self-propelling neural stimulation device to travel within the body tube tree toward a target site located within a gastrointestinal tract of the subject.
12. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to travel within the body tube tree of the subject toward the target site includes causing the untethered self-propelling neural stimulation device to travel within the body tube tree toward a target site located within a urogenital system of the subject.
13. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to travel within the body tube tree of the subject toward the target site includes causing the untethered self-propelling neural stimulation device to travel within the body tube tree toward a target site located within a musculature of the subject.
14. The method of claim 1 , wherein delivering the neural stimulus includes delivering an electrical stimulus.
15. The method of claim 1 , wherein delivering the neural stimulus includes delivering a magnetic stimulus.
16. The method of claim 1 , wherein delivering the neural stimulus includes delivering an optical stimulus.
17. The method of claim 1 , wherein delivering the neural stimulus includes delivering a chemical stimulus.
18. The method of claim 1 , including selecting a target site in proximity to a stimulation target.
19. The method of claim 1 , including selecting the untethered self-propelling neural stimulation device by selecting an untethered self-propelling neural stimulation device sized to fit within the target site.
20. The method of claim 1 , including selecting the untethered self-propelling neural stimulation device from an assortment of untethered self-propelling neural stimulation devices of different sizes.
21. The method of claim 1 , adjusting the size of the untethered self-propelling neural stimulation device to fit within the target site.
22. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to travel within a body tube tree of a subject toward a target site includes causing the untethered self-propelling neural stimulation device to travel within the body tube tree under the control of a remote portion.
23. The method of claim 1 , including engaging a wall of the body tube tree by causing at least a portion of the untethered self-propelling neural stimulation device to expand to form a pressure fit with the wall of the body tube tree.
24. The method of claim 1 , including engaging a wall of the body tube tree by releasing an adhesive material from the untethered self-propelling neural stimulation device.
25. The method of claim 1 , including engaging a wall of the body tube tree by extending at least one claw or barb-like structure from the untethered self-propelling neural stimulation device to penetratingly engage the wall of the body tube tree.
26. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to stop traveling upon reaching the target site includes causing the untethered self-propelling neural stimulation device to stop traveling upon reaching the target site by engaging the wall of the body tube tree at the target site.
27. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to stop traveling upon reaching the target site includes causing the untethered self-propelling neural stimulation device to stop traveling upon reaching the target site by discontinuing propulsion of the untethered self-propelling neural stimulation device.
28. The method of claim 1 , wherein causing the untethered self-propelling neural stimulation device to stop traveling upon reaching the target site includes causing the untethered self-propelling neural stimulation device to stop traveling upon reaching the target site by applying a force to oppose propulsion of the untethered self-propelling neural stimulation device.
29. The method of claim 1 , including causing the untethered self-propelling neural stimulation device to resume traveling.
30. The method of claim 1 , including carrying at least one additional neural stimulation device with the untethered self-propelling neural stimulation device.
31. The method of claim 1 , further comprising recording bioelectromagnetic activity from the target site with the untethered self-propelling neural stimulation device.
32. The method of claim 1 , wherein selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, an index of refraction, a pressure, a temperature, a blood flow, a direction of blood flow, a viscosity, a shear, a pH, a presence or absence of a chemical, or a man-made structure, comprises:
selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, or an index of refraction.
33. The method of claim 1 , wherein selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, an index of refraction, a pressure, a temperature, a blood flow, a direction of blood flow, a viscosity, a shear, a pH, a presence or absence of a chemical, or a man-made structure, comprises:
selecting a branch at the branch point at least partially based on detecting one or more of a pressure, a temperature, a blood flow, a direction of blood flow, a viscosity, a shear, a pH, and a presence or absence of a chemical.
34. The method of claim 1 , wherein selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, an index of refraction, a pressure, a temperature, a blood flow, a direction of blood flow, a viscosity, a shear, a pH, a presence or absence of a chemical, or a man-made structure, comprises:
selecting a branch at the branch point at least partially based on detecting a man-made structure.
35. A method of emplacing a neural stimulation device, comprising:
causing an untethered self-propelling neural stimulation device to travel within a CSF-space of a subject toward a target site;
detecting with a sensor on the untethered self-propelling neural stimulation device a branch point including two or more branches within the CSF-space;
selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, an index of refraction, a pressure, a temperature, a fluid flow, a direction of fluid flow, a viscosity, a shear, a pH, a presence or absence of a chemical, or a man-made structure;
upon detecting the branch point, causing the untethered self-propelling neural stimulation device to enter the branch leading toward the target site;
causing the untethered self-propelling neural stimulation device to stop traveling upon reaching the target site; and
delivering a neural stimulus at the target site.
36. The method of claim 35 , wherein selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, an index of refraction, a pressure, a temperature, a fluid flow, a direction of fluid flow, a viscosity, a shear, a pH, a presence or absence of a chemical, or a man-made structure, comprises:
selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, or an index of refraction.
37. The method of claim 35 , wherein selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, an index of refraction, a pressure, a temperature, a fluid flow, a direction of fluid flow, a viscosity, a shear, a pH, a presence or absence of a chemical, or a man-made structure, comprises:
selecting a branch at the branch point at least partially based on detecting one or more of a pressure, a temperature, a fluid flow, a direction of fluid flow, a viscosity, a shear, a pH, and a presence or absence of a chemical.
38. The method of claim 35 , wherein selecting a branch at the branch point at least partially based on detecting one or more of an electrical resistivity, a density, a sound speed, an osmolality, an index of refraction, a pressure, a temperature, a fluid flow, a direction of fluid flow, a viscosity, a shear, a pH, a presence or absence of a chemical, or a man-made structure, comprises:
selecting a branch at the branch point at least partially based on detecting a man-made structure.