Drug-loaded poly (alkyl-cyanoacrylate) nanoparticles and process for the preparation thereof
A process for preparing the drug-loaded cyanoacrylate nanoparticles is described. The cyanoacrylate nanoparticles which effectively deliver biological and therapeutic agents are synthesized by miniemulsion polymerization with surfactant, pluronic F127 or F68. Before initiation of polymerization, active agents with particularly highly hydrophobicity are dissolved in cyanoacrylate monomer. Compared with the drug-loaded polyalkylcyanoacrylate nanoparticles produced by emulsion polymerization, those produced by miniemulsion polymerization possess higher loading and encapsulation efficiencies. While the content of dissolved agents increases, furthermore, the loading and encapsulation efficiencies increase concurrently.
1. A method for preparing drug-loaded poly(n-butyl-cyanoacrylate) nanoparticles, the method comprising the steps of:
forming a solution by dissolving a hydrophobic active agent in a poly(n-butyl-cyanoacrylate) medium while applying heating and sonication;
adding an aqueous surfactant solution to the solution while stirring to yield a pre-emulsion; and
sonicating the pre-emulsion followed by stirring to form the drug-loaded poly(n-butyl-cyanoacrylate) nanoparticles, wherein the hydrophobic active agent is paclitaxel or flutamide.