Cardiac flow quantification with volumetric imaging data

1. A method of quantifying cardiac volume flow for an imaging sequence, the method comprising:

receiving data representing three dimensions and color Doppler flow data over a plurality of frames;

constructing a four-dimensional ventricular model based on the data representing three dimensions for the plurality of frames, the four-dimensional ventricular model comprising a sampling plane configured to measure the cardiac volume flow;

computing volume flow samples based on the sampling plane and the color Doppler flow data; and

correcting the volume flow samples for aliasing based on volumetric change in the four-dimensional ventricular model between successive frames of the plurality of frames.

2. The method of claim 1 , wherein correcting the flow samples for aliasing comprises determining a de-aliasing correction factor based on a ratio between the volumetric change in the four-dimensional ventricular model and the computed volume flow samples for the successive frames.

3. The method of claim 1 , wherein constructing the four-dimensional ventricular model comprises:

tracking motion of a ventricular boundary between the successive frames; and

adjusting the sampling plane based on the tracked motion.

4. The method of claim 3 , wherein tracking the motion comprises:

determining temporal displacement of model points between successive frames of the plurality of frames; and

finding deformations, with a boundary detecting tracker, in each frame of the plurality of frames with maximal probability.

5. The method of claim 3 , wherein tracking the motion comprises propagating anatomical boundaries and deformations using a Bayesian framework.

6. The method of claim 1 , wherein constructing the four-dimensional ventricular model comprises optimizing the sampling plane for each frame of the plurality of frames.

7. The method of claim 1 , wherein constructing the four-dimensional ventricular model comprises aligning temporal deformations in the four-dimensional ventricular model via four-dimensional generalized procrustes analysis.

8. The method of claim 1 , wherein constructing the four-dimensional ventricular model comprises computing a low-dimensional embedding based on aligned training sequences.

9. The method of claim 1 , wherein constructing the four-dimensional ventricular model comprises grouping motion sequences with hierarchical K-means clustering.

10. The method of claim 1 , wherein the sampling plane is one of a plurality of sampling planes defined by the four-dimensional ventricular model.

11. The method of claim 1 , wherein the data representing three dimensions is based on volume color Doppler data.

12. A system for quantifying cardiac volume flow for an imaging sequence, the system comprising:

an image acquisition system configured to capture data representing three dimensions and color Doppler flow data over a plurality of frames; and

a processor in communication with the image acquisition system to receive the data representing three dimensions and the color Doppler flow data and configured to:

construct a four-dimensional ventricular model based on the data representing three dimensions, the four-dimensional ventricular model being configured to track motion of a ventricular boundary between successive frames of the plurality of frames;

define a sampling plane based on the four-dimensional ventricular model for a first frame of the plurality of frames, the sampling plane being configured to measure the cardiac volume flow;

adjust the sampling plane for a second frame of the plurality of frames based on the motion tracked by the four-dimensional ventricular model; and

sample the color Doppler flow data for the second frame via the adjusted sampling plane.

13. The system of claim 12 , wherein the processor is further configured to correct the sampled color Doppler flow data for aliasing based on volumetric change in the ventricular model between successive frames of the plurality of frames.

14. The system of claim 13 , wherein the processor is further configured to determine a de-aliasing correction factor based on a ratio between the volumetric change in the four-dimensional ventricular model and the sampled color Doppler flow data for the successive frames.

15. The system of claim 12 , wherein the processor, in constructing the four-dimensional ventricular model, is further configured to:

determine temporal displacement of model points between successive frames of the plurality of frames; and

identify deformations in each frame of the plurality of frames with maximal probability.

16. The system of claim 12 , wherein the processor, in constructing the four-dimensional ventricular model, is further configured to propagate anatomical boundaries and deformations using a Bayesian framework.

17. The system of claim 12 , wherein the processor is further configured to optimize the sampling plane for each frame of the plurality of frames.

18. The system of claim 12 , wherein the processor, in constructing the four-dimensional ventricular model, is further configured to align temporal deformations in the four-dimensional ventricular model via four-dimensional generalized procrustes analysis.

19. The system of claim 12 , wherein the processor, in constructing the four-dimensional ventricular model, is further configured to compute a low-dimensional embedding based on aligned training sequences.

20. The system of claim 12 , wherein the processor, in constructing the four-dimensional ventricular model, is further configured to group motion sequences with hierarchical K-means clustering.