Composition comprising crustacean gastrolith components and its use
View Patent ↗Provided is a formulation containing amorphous or microcrystalline calcium carbonate finely interspersed with organic matter in a ratio of 10 parts of the carbonate per 1 to 3 parts of the organic matter, wherein the organic matter consists of chitin and polypeptide. The formulation is efficient in treating various pathological conditions, including proliferative diseases, neurological disorders, and musculoskeletal disorders.
1. A method for treating breast carcinoma comprising orally administering a pharmaceutical composition consisting of
(A) dried, ground crustacean gastrolith having
(i) 100 weight parts (wp) of calcium carbonate finely mixed with
(ii) from 10 to 30 wp of organic matter having
(a) from 90 to 99 wt % chitin and
(b) from 1 to 10 wt % polypeptide,
(iii) up to 30 wp of moisture per 100 wp of calcium carbonate, and
(iv) up to 40 wp of inorganic salts other than calcium carbonate, and
(B) a pharmaceutical carrier, a pharmaceutical binding agent, or a pharmaceutical diluent.
2. The method according to claim 1 , wherein said inorganic salts are selected from the group consisting of magnesium, potassium, strontium, sodium, phosphate, sulfate, chloride, bromide, and fluoride.
3. The method according to claim 1 , wherein the calcium carbonate in said composition is amorphous.
4. The method according to claim 1 , wherein said breast carcinoma further comprises metastasis in other organs.
5. The method according to claim 4 , wherein said metastasis is bone metastasis.
6. The method according to claim 1 , wherein said treating comprises shrinking tumors, stopping their growth, or slowing down or inhibiting the cell proliferation in a tumor.
7. The method according to claim 1 , wherein said treating further comprises alleviating pain associated with said breast carcinoma.
8. The method according to claim 1 , wherein said composition is administered orally in daily doses of from about 0.5 to about 3 g.
9. The method according to claim 1 , wherein said composition is in the form of a tablet.
10. A method for treating breast carcinoma comprising orally administering a pharmaceutical composition consisting of
(A) dried, ground crustacean gastrolith having
(i) 100 weight parts (wp) of calcium carbonate finely mixed with
(ii) from 10 to 30 wp of organic matter having
(a) from 90 to 99 wt % chitin and
(b) from 1 to 10 wt % polypeptide,
(iii) up to 30 wp of moisture per 100 wp of calcium carbonate, and
(iv) up to 40 wp of inorganic salts other than calcium carbonate.
11. The method according to claim 10 , wherein said inorganic salts are selected from the group consisting of magnesium, potassium, strontium, sodium, phosphate, sulfate, chloride, bromide, and fluoride.
12. The method according to claim 10 , wherein the calcium carbonate in said composition is amorphous.
13. The method according to claim 10 , wherein said breast carcinoma further comprises metastasis in other organs.
14. The method according to claim 13 , wherein said metastasis is bone metastasis.
15. The method according to claim 10 , wherein said treating comprises shrinking tumors, stopping their growth, or slowing down or inhibiting the cell proliferation in a tumor.
16. The method according to claim 10 , wherein said treating further comprises alleviating pain associated with said breast carcinoma.
17. The method according to claim 10 , wherein said composition is administered orally in daily doses of from about 0.5 to about 3 g.
18. The method according to claim 10 , wherein said composition is in the form of a tablet.