IP Library › Granted Patent US 8,759,507
Granted Patent B2
US 8,759,507 · App. 12/976,381 · Granted Jun 24, 2014

Modulation of exon recognition in pre-mRNA by interfering RNA structure

Inventor: Judith Christina Theodora Van Deutekom (Dordrecht, NL)
Assignee: Academisch Ziekenhuis Leiden
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,759,507
App. No.
12/976,381
Granted
Jun 24, 2014
Kind
B2
Abstract

The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and methods in the treatment of disease. Further provided are pharmaceutical compositions and methods and means for inducing skipping of several exons in a pre-mRNA.

Claims (2)

1. An oligonucleotide consisting of SEQ ID NO. 27, wherein each ribose moiety of said oligonucleotide is 2′—O—methyl substituted.

2. The oligonucleotide of claim 1 , wherein each internucleoside linkage of said oligonucleotide is a phosphorothioate internucleoside linkage.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2013
From: VAN DEUTEKOM, JUDITH CHRISTINA THEODORA, DR.
To: ACADEMISCH ZIEKENHUIS LEIDEN
Reel/Frame 029733/0786 →
Continuity (4)
Division 12198007 · Aug 25, 2008
Continuation 11233495 · Sep 21, 2005
Continuation PCTNL0300214 · Mar 21, 2003
Related Publication 20110312086A1 · Dec 22, 2011