Antiviral and antibacterial activity from medicinal mushrooms
View Patent ↗Compounds having unique antiviral and antibacterial properties are prepared from medicinal mushroom mycelium, extracts and derivatives. The compositions are derived from Fomitopsis, Piptoporus, Ganoderma, Inonotus, Trametes, Pleurotus , and blends of medicinal mushroom species and are useful in preventing and treating viruses including Poxyiridae and Orthopox viruses, flu viruses including bird flu (H5N1), SARS and Hepatitis C (HCV), as well as infections from Mycobacterium tuberculosis, Staphylococcus aureus and Escherichia coli.
1. A composition for restricting the growth, spread and survivability of a virus comprising an aqueous ethanol extract of a mycelium of a medicinal mushroom wherein the virus is selected from the group consisting of influenza, including influenza A H5N1 and H3N2 and influenza B, avian influenza and Herpes Simplex I and II, wherein the medicinal mushroom is Fomitopsis officinalis and wherein the extract has a selectivity index (SI=CC 50 /EC 50 ) against the virus ≧10.
2. The composition of claim 1 , wherein the mycelium is selected from the group consisting of live mycelium, dried mycelium, freeze dried mycelium or a combination thereof.
3. The composition of claim 1 , wherein the aqueous ethanol extract is administered in a form selected from the group consisting of orally-active powders, pills, capsules, teas, extracts, dried extracts, sublinguals, sprays, dispersions, solutions, suspensions, emulsions, foams, syrups, lotions, ointments, gels, pastes, dermal patches, injectables, vaginal creams and suppositories.
4. The composition of claim 1 , wherein the composition additionally comprises a mycelial extract selected from the group consisting of, Ganoderma resinaceum and G. annulare extracts, Inonotus obliquus extracts, Hypsizygus ulmarius and H. tessulatus extracts and Trametes versicolor extracts.
5. The composition of claim 1 , wherein the extract inhibits bacteria selected from the group consisting of Escherichia coli and Staphylococcus aureus.
6. The composition of claim 2 , wherein the live mycelium is grown on a grain.
7. A composition comprising an aqueous ethanol extract of Fomitopsis officinalis mycelium wherein the extract has an antiviral activity Selectivity Index (SI=CC 50 /EC 5 O) against flu viruses that is ≧10 and the survivability of the flu viruses is limited upon contact with the extract of Fomitopsis officinalis.
8. A composition for limiting the survivability of flu viruses upon contact with the composition while selectively not harming healthy human cells comprising an aqueous ethanol extract of live Fomitopsis officinalis mycelium wherein the extract has a Selectivity Index (SI=CC 50 /EC 50 ) against a flu virus that is ≧10.
9. A composition for limiting the susceptibility of human cells to infection by a flu virus, wherein the composition contacts the flu virus prior to the flu virus contacting said cells, and wherein the composition comprises an aqueous ethanol extract of Fomitopsis officinalis mycelium with a calculated Selectivity Index (SI=CC 50 /EC 50 ) against a flu virus that is ≧10.
10. A composition for restricting the growth, spread and survivability of a virus comprising an aqueous ethanol Fomitopsis officinalis extract, wherein the virus is an influenza virus, and wherein the influenza virus is an influenza virus selected from the group consisting of: influenza A H5N1 and H3N2, influenza B and avian influenza, and wherein the extract has a selectivity index (SI) against the influenza >100.
11. The composition of claim 10 , wherein the mycelium of a mycelium of a Fomitopsis medicinal mushroom is selected from the group consisting of live mycelium, dried mycelium, freeze dried mycelium or a combination thereof.
12. The composition of claim 10 , wherein the composition additionally comprises a mycelial extract selected from the group consisting of, Ganoderma resinaceum and G. annulare extracts, Inonotus obliquus extracts, Hypsizygus ulmarius and H. tessulatus extracts and Trametes versicolor extracts.
13. The composition of claim 10 , wherein the live mycelium is grown on a grain.
14. A composition for restricting the growth, spread and survivability a virus comprising an aqueous ethano extract of a medicinal mushroom mycelium wherein the virus is selected from the group consisting of influenza, wherein the influenza is influenza A H5N1 and H3N2, Influenza B, or avian influenza, or Herpes Simplex I and/or II, wherein the medicinal mushroom mycelium is Fomitopsis officianalis and wherein the extract has a selectivity index (SI) against the virus ≧10 and inhibits bacteria, wherein the bacteria is selected from the group consisting of Stapylococcus aureaus and Escheria coli , and wherein inhibition of the bacteria is greater than 99%.
15. The composition of claim 14 , wherein the mycelium is selected from the group consisting of live mycelium, dried mycelium, freeze dried mycelium or a combination thereof.
16. A composition for restricting the growth, spread and survivability of a virus comprising an aqueous ethanol extract of a medicinal mushroom mycelium wherein the virus is influenza, wherein the medicinal mushroom mycelium is Fomitopsis officinalis mycelium and wherein the aqueous ethanol extract has a selectivity index (SI) against influenza ≧10 and inhibits bacteria selected from the group consisting of Stapylococcus aureaus and Escheria coli , and wherein inhibition of the bacteria is greater than 99%.
17. The composition of claim 16 , wherein the mycelium is selected from the group consisting of live mycelium, dried mycelium, freeze dried mycelium or a combination thereof.