Medical components having coated surfaces exhibiting low friction and low reactivity

1. A medical article comprising a substrate having a coating on a surface thereof, the coating comprising: (1) at least one organopolysiloxane and (2) a deposition product applied to the at least one organopolysiloxane by plasma-enhanced chemical vapor deposition of a composition comprising at least one monomer selected from the group consisting of N-vinyl pyrrolidone, vinyl acetate, ethylene oxide, alkyl acrylate, alkyl methacrylate, acrylamide, acrylic acid, and mixtures thereof.

2. The medical article according to claim 1 , wherein the medical article is selected from the group consisting of a chamber and a sealing member.

3. The medical article according to claim 2 , wherein the chamber has a contact surface adapted to sealingly engage a contact surface of a sealing member for a medical article.

4. The medical article according to claim 3 , wherein the coating comprises the contact surface of the chamber.

5. The medical article according to claim 1 , wherein the chamber is selected from the group consisting of a syringe barrel, drug cartridge container, needleless injector container, liquid dispensing device container, liquid metering device container, sample collection tube, catheter, and vial.

6. The medical article according to claim 5 , wherein the chamber is a syringe barrel.

7. The medical article according to claim 1 , wherein the chamber is formed from glass, metal, ceramic, plastic, or combinations thereof.

8. The medical article according to claim 7 , wherein the chamber is prepared from an olefinic polymer selected from the group consisting of polyethylene, polypropylene, poly(1-butene), poly(2-methyl-1-pentene), cyclic polyolefins, and mixtures thereof.

9. The medical article according to claim 2 , wherein the sealing member has a contact surface adapted to sealingly engage a contact surface of a chamber for a medical article.

10. The medical article according to claim 9 , wherein the coating comprises the contact surface of the sealing member.

11. The medical article according to claim 2 , wherein the sealing member is selected from the group consisting of a stopper, O-ring, V-ring, plunger tip, and piston.

12. The medical article according to claim 2 , wherein the sealing member is formed from rubber.

13. The medical article according to claim 1 , wherein the organopolysiloxane is polydimethylsiloxane.

14. The medical article according to claim 1 , wherein the organopolysiloxane is represented by the following structural Formula (I):

wherein each R is an independently selected alkyl group and Z is about 30 to about 4,500.

15. The medical article according to claim 1 , wherein the alkyl acrylate is selected from the group consisting of methyl acrylate, ethyl acrylate, butyl acrylate, and mixtures thereof.

16. The medical article according to claim 1 , wherein the alkyl methacrylate is methyl methacrylate.

17. The medical article according to claim 1 , wherein the monomer is N-vinyl pyrrolidone.

18. The medical article according to claim 1 , wherein the concentration of the at least one organopolysiloxane is greater near the surface of the substrate.

19. The medical article according to claim 1 , wherein a portion of the at least one organopolysiloxane is adjacent to an outer surface of the coating.

20. The medical article according to claim 1 , wherein a portion of the at least one monomer chemically reacts with a portion of the at least one organopolysiloxane.

21. The medical article according to claim 1 , wherein the at least one organopolysiloxane is applied to the surface of the substrate; and the deposition product is applied to the at least one organopolysiloxane by plasma-enhanced chemical vapor deposition.

22. The medical article according to claim 1 , wherein the deposition of the at least one monomer forms an integrated coating with the at least one organopolysiloxane.

23. A syringe barrel having a coating on an inner surface thereof, the coating comprising at least one organopolysiloxane applied to the inner surface of the syringe barrel and a deposition product applied thereon, the deposition product being prepared by plasma-enhanced chemical vapor deposition of a composition comprising at least one monomer selected from the group consisting of N-vinyl pyrrolidone, vinyl acetate, ethylene oxide, alkyl acrylate, alkyl methacrylate, acrylamide, acrylic acid, and mixtures thereof.

24. A method for coating a surface of a medical article, comprising:

(a) applying a first coating comprising at least one organopolysiloxane to a surface of a substrate; and

(b) applying a deposition product to at least a portion of the first coating by plasma-enhanced chemical vapor deposition of a composition comprising at least one monomer selected from the group consisting of N-vinyl pyrrolidone, vinyl acetate, ethylene oxide, alkyl acrylate, alkyl methacrylate, acrylamide, acrylic acid, and mixtures thereof.

25. A method for lubricating an interface between an inner surface of a chamber and an exterior surface of a sealing member of a medical article, comprising:

(a) applying a first coating comprising at least one organopolysiloxane onto the interior surface of the chamber and/or the exterior surface of the sealing member;

(b) applying a deposition product to at least a portion of the first coating by plasma-enhanced chemical vapor deposition of a composition comprising at least one monomer selected from the group consisting of N-vinyl pyrrolidone, vinyl acetate, ethylene oxide, alkyl acrylate, alkyl methacrylate, acrylamide, acrylic acid, and mixtures thereof.

26. The medical article according to claim 1 , wherein a higher concentration of the deposition product of the at least one monomer is present near an outer surface of the coating compared to within a bulk of the coating.