Processes for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
The present invention relates to compounds and processes for preparing compounds of Formula (I), including compounds such as trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof (e.g., NXL-104).
1. A compound of Formula (VI) or a salt or an analog thereof
2. The compound according to claim 1 , wherein the compound has Formula (VII):
3. A process for making sodium ({[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl]oxy}sulphonyl)oxidanide comprising treating the compound of claim 1 with a protecting group and a carbonylation agent.
4. The process of claim 3 , wherein the protecting group is selected from the group consisting of 9-fluorenylmethoxycarbonyl, tert-butoxycarbonyl, benzyloxycarbonyl ethyloxycarbonyl, methyloxycarbonyl, phenoxycarbonyl and allyloxycarbonyl.
5. The process of claim 3 , wherein the protecting group is 9-fluorenylmethoxycarbonyl.
6. The process of claim 3 , wherein the carbonylation agent is selected from the group consisting of phosgene, triphosgene and carbonyl diimidazole.
7. The process of claim 3 , wherein the carbonylation agent is N,N-carbonyl diimidazole.