IP Library › Granted Patent US 8,835,556
Granted Patent B2
US 8,835,556 · App. 13/474,548 · Granted Sep 16, 2014

Hydrolytically stable maleimide-terminated polymers

Inventors: Antoni Kozlowski (Huntsville, AL); Remy F. Gross, III (Petaluma, CA); Samuel P. McManus (Huntsville, AL)
Assignee: Nektar Therapeutics
C08G65/33396C08L2203/02A61K47/48215C08G65/3337
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Quick Facts
Patent No.
US 8,835,556
App. No.
13/474,548
Granted
Sep 16, 2014
Kind
B2
Abstract

The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.

Claims (6)

1. A conjugate formed by the reaction of an active agent comprising a reactive amino group and a thiol group with a water-soluble polymer having the structure:

wherein (n) is 3 to 3000 and further wherein the conjugate so formed has of the following structure

wherein (n) is 3 to 3000 and —NH— of “—NH-active agent” corresponds to the amino group of the active agent, wherein the active agent is selected from the group consisting of peptides and proteins.

2. The conjugate of claim 1 , wherein (n) is 20 to 1000.

3. The conjugate of claim 1 , wherein the active agent is a peptide.

4. The conjugate of claim 1 , wherein the active agent is a protein.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 28571, FRAME 0141 Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036866/0700 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
GRANT OF SECURITY INTEREST Recorded Jul 17, 2012
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 028571/0141 →
Continuity (6)
Continuation 13336886 · Dec 23, 2011
Continuation 12229650 · Aug 26, 2008
Continuation 11091024 · Mar 25, 2005
Continuation In Part 10751274 · Dec 31, 2003
Provisional Application 60437211 · Dec 31, 2002
Related Publication 20120226022A1 · Sep 6, 2012