Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecu le, and a tridentate chelator that may complex the radionuclide. The bioactive molecule may be a peptide or somatostatin.
1. A compound represented by:
a pharmaceutically acceptable salt thereof;
f is an integer from 0 to 12; and
g is an integer from 0 to 12.
2. The compound of claim 1 , wherein f is 2 to 10.
3. The compound of claim 1 , wherein f is 4.
4. The compound of claim 1 , wherein g is 2 to 10.
5. The compound of claim 1 , wherein g is 4.
6. The compound of claim 1 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
7. The compound of claim 6 , wherein f is 4.
8. The compound of claim 1 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
9. The compound of claim 8 , wherein g is 4.
10. The compound of claim 1 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
11. The compound of claim 10 , wherein g is 4.
12. The compound of claim 1 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
13. The compound of claim 12 , wherein f is 4.
14. A method of preparing a peptide conjugate incorporating a compound, the method comprising synthesizing the peptide conjugate using solid-phase peptide-synthesis techniques;
wherein:
the compound is:
a pharmaceutically acceptable salt thereof;
f is an integer from 0 to 12; and
g is an integer from 0 to 12.
15. The method of claim 14 , wherein f is 2 to 10.
16. The method of claim 14 , wherein f is 4.
17. The method of claim 14 , wherein g is 2 to 10.
18. The method of claim 14 , wherein g is 4.
19. The method of claim 14 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
20. The method of claim 19 , wherein f is 4.
21. The method of claim 14 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
22. The method of claim 21 , wherein g is 4.
23. The method of claim 14 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
24. The method of claim 23 , wherein g is 4.
25. The method of claim 14 , wherein the compound is:
or
a pharmaceutically acceptable salt thereof.
26. The method of claim 25 , wherein f is 4.