IP Library Granted Patent US 8,846,375
Granted Patent B2
US 8,846,375 · App. 13/941,353 · Granted Sep 30, 2014

Tailored oils

Inventors: Scott Franklin (La Jolla, CA); Aravind Somanchi (Redwood City, CA); George Rudenko (Mountain View, CA); Riyaz Bhat (South San Francisco, CA); Xinhua Zhao (Foster City, CA); Risha Bond (Mountain View, CA); Walter Rakitsky (San Diego, CA); Alejandro Marangoni (Guelph, CA); Diza Braksmayer (Chanhassen, MN)
Assignee: Solazyme, Inc.
C12P33/00A23D9/00C12P7/64C12P7/6409C07J9/00C12P7/6463C07C57/03C12P7/6472
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Quick Facts
Patent No.
US 8,846,375
App. No.
13/941,353
Granted
Sep 30, 2014
Kind
B2
Abstract

Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced oxidative or thermal stability, or can be useful as a frying oil, shortening, roll-in shortening, tempering fat, cocoa butter replacement, as a lubricant, or as a feedstock for various chemical processes. The fatty acid profile can be enriched in midchain profiles or the oil can be enriched in triglycerides of the saturated-unsaturated-saturated type.

Claims (6)

1. A recombinant vector construct or an isolated host cell comprising, a nucleic acid encoding a protein having at least 95% identity to SEQ ID NO: 77, wherein the protein has lysophosphatidic acid acyltransferase (LPAAT) activity.

2. The recombinant vector construct, or host cell of claim 1 , encoding a protein having at least 98% identity to SEQ ID NO: 77.

3. A recombinant vector construct or an isolated host cell comprising, a nucleic acid encoding a protein having at least 95% identity to SEQ ID NO: 78, wherein the protein has lysophosphatidic acid acyltransferase (LPAAT) activity.

4. The recombinant vector construct or host cell of claim 3 , encoding a protein having at least 98% identity to SEQ ID NO: 78 .

5. A recombinant vector construct or an isolated host cell comprising, a nucleic acid encoding a protein having at least 95% identity to SEQ ID NO: 79, wherein the protein has lysophosphatidic acid acyltransferase (LPAAT) activity.

6. The recombinant vector construct or host cell of claim 5 , encoding a protein having at least 98% identity to SEQ ID NO: 79.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2017
From: TERRAVIA HOLDINGS, INC.
To: CORBION BIOTECH, INC.
Reel/Frame 044424/0211 →
CHANGE OF NAME Recorded May 23, 2016
From: SOLAZYME, INC.
To: TERRAVIA HOLDINGS, INC.
Reel/Frame 038794/0867 →
Continuity (11)
Continuation 13865974 · Apr 18, 2013
Provisional Application 61635285 · Apr 18, 2013
Provisional Application 61639838 · Apr 27, 2012
Provisional Application 61655469 · Jun 4, 2012
Provisional Application 61672196 · Jul 16, 2012
Provisional Application 61679026 · Aug 2, 2012
Provisional Application 61715998 · Oct 19, 2012
Provisional Application 61769678 · Feb 26, 2013
Provisional Application 61778963 · Mar 13, 2013
Provisional Application 61809213 · Apr 5, 2013
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