Sweet flavor modifier

1. A compound having structural Formula (Ia):

or a salt or solvate thereof;

wherein,

m is 4, and n is 0; or m is 3, and n is 1; or m and n are both 2;

q is 0, 1, 2, or 3;

X is a covalent bond or —NR 1 —;

R 1 is hydrogen or C1 to C6 alkyl;

Y is alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroarylalkyl, or substituted heteroarylalkyl; and

each R 2 is independently selected from the group consisting of alkyl, heteroalkyl, halo, hydroxyl, alkoxy, amino, alkylamino, cyano, nitro, haloalkyl, carboxylic acid, amide, ester, acyl, thiol, alkylthio, and sulfonamide,

wherein the substituents are selected from the group consisting of —R a , halo, —O, ═O, —OR b , —SR b , —S − , ═S, —NR c R c , ═NR b , ═N—OR b , —CF 3 , —CN, —OCN, —SCN, —S(O) 2 R b , —S(O) 2 NR b , —S(O) 2 O − , —S(O) 2 OR b , —OS(O) 2 R b , —OS(O) 2 O − , —OS(O) 2 OR b , —C(O)R b , —C(S)R b , —C(NR b )R b , —C(O)O − , —C(O)OR b , —C(S)OR b , —C(O)NR c R c , —C(NR b )NR c R c , —OC(O)R b , —OC(S)R b , —OC(O)O − , —OC(O)OR b , —OC(S)OR b , —NR b C(O)R b , —NR b C(S)R b , —NR b C(O)O − , —NR b C(O)OR b , —NR b C(S)OR b , —NR b C(O)NR c R c , —NR b C(NR b )R b and —NR b C(NR b )NR c R c , where R a is selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl; each R b is independently hydrogen or R a ; and each R e is independently R b or alternatively, the two R c s may be taken together with the nitrogen atom to which they are bonded form a 4-, 5-, 6- or 7-membered cycloheteroalkyl which may optionally include from 1 to 4 of the same or different additional heteroatoms selected from the group consisting of O, N and S.

2. The compound of claim 1 , wherein X is NH.

3. The compound of claim 1 , wherein X is a covalent bond.

4. The compound of claim 1 , which is represented by structural Formula (Ib):

wherein,

Y is alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroarylalkyl, or substituted heteroarylalkyl.

5. The compound of claim 1 , which is represented by structural Formula (Ic):

wherein,

Y is alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroarylalkyl, or substituted heteroarylalkyl.

6. The compound of claim 1 , which is represented by structural Formula (Id):

wherein,

Y is alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroarylalkyl, or substituted heteroarylalkyl.

7. The compound of claim 1 , which is represented by structural Formula (Ie):

wherein,

Y is alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aralkyl, heteroarylalkyl, or substituted heteroarylalkyl.

8. The compound of claim 4 , wherein Y is —(C1 to C3 alkylene)-aryl or —(C1 to C3 alkylene)-substituted aryl.

9. The compound of claim 4 , wherein Y is —(C1 to C3 alkylene)-heteroaryl or —(C1 to C3 alkylene)-substituted heteroaryl.

10. The compound of claim 5 , wherein Y is C1 to C12 alkyl, substituted C1 to C12 alkyl, five or six-membered heteroaryl, substituted five or six-membered heteroaryl, —(C1 to C3 alkylene)-(five or six-membered heteroaryl), or —(C1 to C3 alkylene)-(substituted five or six-membered heteroaryl).

11. The compound of claim 4 , wherein Y is C1 to C12 alkyl, substituted C1 to C12 alkyl, C1 to C12 heteroalkyl, or substituted C1 to C12 heteroalkyl.

12. The compound of claim 4 , wherein Y is three to seven-membered cycloalkyl, substituted three to seven-membered cycloalkyl, five to seven-membered heterocyclyl, or substituted five to seven-membered heterocyclyl.

13. The compound of claim 4 , wherein Y is phenyl or substituted phenyl.

14. The compound of claim 4 , wherein Y is an optionally substituted five or six-membered monocyclic heteroaryl, or an optionally substituted ten to twelve-membered bicyclic heteroaryl.

15. The compound of claim 1 , which is selected from the group consisting of

16. The compound of claim 7 , wherein Y is C1 to C12 alkyl, substituted C1 to C12 alkyl, five or six-membered heteroaryl, substituted five or six-membered heteroaryl, —(C1 to C3 alkylene)-(five or six-membered heteroaryl), or —(C1 to C3 alkylene)-(substituted five or six-membered heteroaryl).

17. The compound of claim 6 , wherein Y is C1 to C12 alkyl, substituted C1 to C12 alkyl, C1 to C12 heteroalkyl, or substituted C1 to C12 heteroalkyl.

18. The compound of claim 6 , wherein Y is three to seven-membered cycloalkyl, substituted three to seven-membered cycloalkyl, five to seven-membered heterocyclyl, or substituted five to seven-membered heterocyclyl.

19. The compound of claim 6 , wherein Y is phenyl or substituted phenyl.

20. The compound of claim 6 , wherein Y is an optionally substituted five or six-membered monocyclic heteroaryl, or an optionally substituted ten to twelve-membered bicyclic heteroaryl.

21. The compound of claim 6 , wherein Y is —(C1 to C3 alkylene)-aryl or —(C1 to C3 alkylene)-substituted aryl.

22. The compound of claim 6 , wherein Y is —(C1 to C3 alkylene)-heteroaryl or —(C1 to C3 alkylene)-substituted heteroaryl.

23. The compound of claim 1 , wherein the substituents are selected from the group consisting of —R a , halo, ═O, —OR b , —NR cR c , —NH 2 , —NH-alkyl, N-pyrrolidinyl, N-morpholinyl, —CF 3 , —CN, —OCN, —C(O)R b , —C(NR b )R b , —C(O)O − , —C(O)OR b , —C(O)NR c R c , —C(NR b )NR c R c , —OC(O)R b , —OC( O)O − , —OC(O)OR b , —NR b C(O)R b , —NR b C(O)O — , —NR b C(O)OR b , —NR b C(O)NR c R c , —NR b C(NR b )R b and —NR b C(NR b )NR c R c , where R a is selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl; each R b is independently hydrogen or Ra; and each R c is independently R b or alternatively, the two Res may be taken together with the nitrogen atom to which they are bonded form a 4-, 5-, 6- or 7-membered cycloheteroalkyl which may optionally include from 1 to 4 of the same or different additional heteroatoms selected from the group consisting of O, N and S.

24. The compound of claim 1 , which is selected from the group consisting of

or a salt or solvate thereof.