Humanized anti-CD19 antibodies
Isolated nucleic acids encoding anti-CD19 mouse monoclonal antibodies are described herein. Also described are expression vectors, host cells and a method of producing anti-CD19 antibodies.
1. An isolated nucleic acid encoding a polypeptide comprising an amino acid sequence comprising SEQ ID NO: 106.
2. An isolated nucleic acid encoding a polypeptide comprising an amino acid sequence comprising SEQ ID NO: 111.
3. An expression vector comprising the nucleic acid of claim 1 .
4. An expression vector comprising the nucleic acid of claim 2 .
5. An expression vector comprising an isolated nucleic acid encoding an antibody comprising the amino acid sequence of SEQ ID NO: 106 and 111, wherein the antibody binds a CD19 antigen.
6. A host cell transfected with the vector of claim 1 .
7. A host cell transfected with the vector of claim 2 .
8. A host cell transfected with the vector of claim 5 .
9. A method of producing an antibody comprising culturing host cells according to claim 8 under conditions for production of the antibody.